Archana Vijayakumar
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Explore the profile of Archana Vijayakumar including associated specialties, affiliations and a list of published articles.
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21
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1078
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Recent Articles
1.
Liu Y, Kimura M, Li X, Sulc J, Wang Q, Rodriguez-Lopez S, et al.
J Hepatol
. 2024 Aug;
82(2):174-188.
PMID: 39181211
Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The...
2.
Vijayakumar A, Manod M, Krishna R, Mathew A, Mohan C
RSC Med Chem
. 2023 Dec;
14(12):2509-2534.
PMID: 38107174
Isoquinoline-enrooted organic small-molecules represent a challenging molecular target in the organic synthesis arsenal attributed to their structural diversity and therapeutic importance. Into the bargain, isoquinolines are significant structural frameworks in...
3.
Hyrina A, Burdette D, Song Z, Ramirez R, Okesli-Armlovich A, Vijayakumar A, et al.
PLoS One
. 2022 Aug;
17(8):e0270273.
PMID: 35925919
Chronic hepatitis B virus (HBV) infection is characterized by the presence of high circulating levels of non-infectious lipoprotein-like HBV surface antigen (HBsAg) particles thought to contribute to chronic immune dysfunction...
4.
Vijayakumar A, Okesli-Armlovich A, Wang T, Olson I, Seung M, Kusam S, et al.
Hepatol Commun
. 2022 Jun;
6(9):2298-2309.
PMID: 35735253
Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl CoA carboxylase (ACC) inhibitors decrease hepatocyte lipotoxicity by inhibiting de...
5.
Lee J, Vijayakumar A, White P, Xu Y, Ilkayeva O, Lynch C, et al.
Endocrinology
. 2021 Mar;
162(7).
PMID: 33765118
Circulating branched chain amino acid (BCAA) levels are elevated in obese humans and genetically obese rodents. However, the relationship of BCAAs to insulin resistance in diet-induced obese mice, a commonly...
6.
Bates J, Vijayakumar A, Ghoshal S, Marchand B, Yi S, Kornyeyev D, et al.
J Hepatol
. 2020 May;
73(4):896-905.
PMID: 32376414
Background & Aims: Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step of de novo...
7.
Syed I, Rubin de Celis M, Mohan J, Moraes-Vieira P, Vijayakumar A, Nelson A, et al.
J Clin Invest
. 2019 Aug;
129(9):3717-3731.
PMID: 31380811
Palmitic acid esters of hydroxy stearic acids (PAHSAs) are endogenous antidiabetic and antiinflammatory lipids. Here, we show that PAHSAs protect against type 1 diabetes (T1D) and promote β cell survival...
8.
Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn B, et al.
Sci Rep
. 2018 Oct;
8(1):15757.
PMID: 30361530
Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs),...
9.
Yang Q, Vijayakumar A, Kahn B
Nat Rev Mol Cell Biol
. 2018 Aug;
19(10):654-672.
PMID: 30104701
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling but also involves the complex interplay of multiple metabolic pathways....
10.
Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani R, Moraes-Vieira P, et al.
Cell Rep
. 2017 Oct;
21(4):1021-1035.
PMID: 29069585
Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue...