Aparna Gudlur
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Explore the profile of Aparna Gudlur including associated specialties, affiliations and a list of published articles.
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11
Citations
410
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Recent Articles
1.
Johnson M, Gudlur A, Zhang X, Xin P, Emrich S, Yoast R, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(29):17369-17380.
PMID: 32641503
Voltage-gated L-type Ca channel (Ca1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell (VSMC) remodeling is a pathological hallmark...
2.
Gudlur A, Zeraik A, Hirve N, Hogan P
J Physiol
. 2019 Jun;
598(9):1695-1705.
PMID: 31228261
The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular...
3.
Mognol G, Gonzalez-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(20):9959-9968.
PMID: 31019078
The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important target of immune...
4.
Pollak A, Liu C, Gudlur A, Mayfield J, Dalton N, Gu Y, et al.
Elife
. 2018 Dec;
7.
PMID: 30520731
Ca signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca signaling have been shown to be phosphorylated, the biochemical...
5.
Gudlur A, Zeraik A, Hirve N, Rajanikanth V, Bobkov A, Ma G, et al.
Nat Commun
. 2018 Nov;
9(1):4536.
PMID: 30382093
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca levels to maintain cellular Ca balance and to support Ca signalling. The prevailing view has been that STIM1 senses reduced ER Ca...
6.
Hirve N, Rajanikanth V, Hogan P, Gudlur A
Cell Rep
. 2018 Jan;
22(1):72-83.
PMID: 29298434
STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca and, through a conformational change in the STIM cytoplasmic domain, control gating of the...
7.
Gudlur A, Hogan P
Adv Exp Med Biol
. 2017 Sep;
993:39-57.
PMID: 28900908
This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of...
8.
Quintana A, Rajanikanth V, Farber-Katz S, Gudlur A, Zhang C, Jing J, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(51):E7083-92.
PMID: 26644574
The stromal interaction molecule (STIM)-ORAI calcium release-activated calcium modulator (ORAI) pathway controls store-dependent calcium entry, a major mechanism of physiological calcium signaling in mammalian cells. The core elements of the...
9.
Gudlur A, Quintana A, Zhou Y, Hirve N, Mahapatra S, Hogan P
Nat Commun
. 2014 Oct;
5:5164.
PMID: 25296861
The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that...
10.
Gudlur A, Zhou Y, Hogan P
Curr Top Membr
. 2013 Jul;
71:33-58.
PMID: 23890110
The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the...