The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2017 Sep 14

PMID 28900908

Citations 10

Authors

Aparna Gudlur

Patrick G Hogan

Affiliations

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Abstract

This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.

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