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Anuj Gaggar

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Articles 96
Citations 6005
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Recent Articles
1.
Xu Z, Gnouamozi G, Rueger S, Shea P, Buti M, Chan H, et al.
Am J Hum Genet . 2024 May; 111(6):1018-1034. PMID: 38749427
Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveraging paired human exome and ultra-deep HBV genome-sequencing data from 567 affected individuals...
2.
Janssen H, Lim Y, Kim H, Sowah L, Tseng C, Coffin C, et al.
JHEP Rep . 2024 Jan; 6(2):100975. PMID: 38274492
Background & Aims: Novel finite therapies for chronic hepatitis B (CHB) are needed, since lifelong treatment is usually required with current available oral antivirals. This phase II study (NCT03615066) evaluated...
3.
Gane E, Dunbar P, Brooks A, Zhang F, Chen D, Wallin J, et al.
J Hepatol . 2023 Dec; 78(3):513-523. PMID: 38133554
Background & Aims: Selgantolimod (GS-9688) is a Toll-like receptor 8 (TLR8) agonist that suppresses HBV in vitro. In a phase II study, we evaluated the safety and efficacy of weekly...
4.
Aggarwal A, Odorizzi P, Brodbeck J, van Buuren N, Moon C, Chang S, et al.
JHEP Rep . 2023 Mar; 5(4):100664. PMID: 36908748
Background & Aims: Patterns of liver HBV antigen expression have been described but not quantified at single-cell resolution. We applied quantitative techniques to liver biopsies from individuals with chronic hepatitis...
5.
Rossi M, Vecchi A, Tiezzi C, Barili V, Fisicaro P, Penna A, et al.
Gut . 2023 Jan; 72(11):2123-2137. PMID: 36717219
Objective: Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to...
6.
Patton M, Orihuela C, Harrod K, Bhuiyan M, Dominic P, Kevil C, et al.
Crit Care . 2023 Jan; 27(1):34. PMID: 36691080
Background: Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not...
7.
Nkongolo S, Mahamed D, Kuipery A, Sanchez Vasquez J, Kim S, Mehrotra A, et al.
J Clin Invest . 2023 Jan; 133(1). PMID: 36594467
Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the underlying mechanisms in humans...
8.
Wagner J, Yuen L, Littlejohn M, Sozzi V, Jackson K, Martin R, et al.
Aliment Pharmacol Ther . 2022 Nov; 57(5):509-523. PMID: 36427857
Backgrounds And Aims: We investigated associations between hepatitis B virus (HBV) genome-length haplotype number (HN) at baseline in subjects with HBeAg-positive chronic hepatitis B (CHB), and the likelihood of achieving...
9.
Zoulim F, Zlotnick A, Buchholz S, Donaldson E, Fry J, Gaggar A, et al.
Nat Rev Gastroenterol Hepatol . 2022 Oct; 19(12):748-750. PMID: 36207612
No abstract available.
10.
Maslac O, Wagner J, Sozzi V, Mason H, Svarovskaia J, Tan S, et al.
J Viral Hepat . 2022 May; 29(8):604-615. PMID: 35582878
Chronic hepatitis B (CHB) is characterized by progression through different phases of hepatitis B virus (HBV) infection and disease. Although not necessary for HBV replication, there is increasing evidence that...