Antti M Haapalainen
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Explore the profile of Antti M Haapalainen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tiensuu H, Haapalainen A, Tissarinen P, Pasanen A, Hallman M, Ramet M
Placenta
. 2024 Aug;
155:60-69.
PMID: 39137705
Introduction: MicroRNAs regulate post-transcriptional gene expression. Their expression has been linked to many pregnancy complications, including preterm birth. Placental microRNA levels differ between preterm and term pregnancies. Not much is...
2.
Tissarinen P, Tiensuu H, Haapalainen A, Ronkainen E, Laatio L, Vaarasmaki M, et al.
Sci Rep
. 2024 May;
14(1):10819.
PMID: 38734716
Currently, there are no accurate means to predict spontaneous preterm birth (SPTB). Recently, we observed low expression of alpha-1 antitrypsin (AAT) in SPTB placentas. Present aim was to compare the...
3.
Pasanen A, Karjalainen M, Zhang G, Tiensuu H, Haapalainen A, Ojaniemi M, et al.
PLoS Genet
. 2023 Oct;
19(10):e1010982.
PMID: 37871108
Background: Preterm birth (<37 weeks of gestation) is a major cause of neonatal death and morbidity. Up to 40% of the variation in timing of birth results from genetic factors,...
4.
Tissarinen P, Tiensuu H, Haapalainen A, Maatta T, Ojaniemi M, Hallman M, et al.
Pediatr Res
. 2023 Feb;
94(2):520-529.
PMID: 36788289
Background: Specific heat shock proteins are associated with pregnancy complications, including spontaneous preterm birth (SPTB). Placental proteomics and whole exome sequencing recently suggested an association between heat shock protein HSPA5...
5.
Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Tiensuu H, Haapalainen A, Tissarinen P, Pasanen A, Maatta T, Huusko J, et al.
BMC Med
. 2022 Apr;
20(1):141.
PMID: 35477570
Background: Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous...
6.
Huusko J, Tiensuu H, Haapalainen A, Pasanen A, Tissarinen P, Karjalainen M, et al.
Sci Rep
. 2021 Aug;
11(1):17115.
PMID: 34429451
Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat...
7.
Haapalainen A, Daddali R, Hallman M, Ramet M
J Cell Mol Med
. 2021 May;
25(13):6304-6317.
PMID: 34009729
Protein kinases and phosphatases regulate cellular processes by reversible phosphorylation and dephosphorylation events. CPPED1 is a recently identified serine/threonine protein phosphatase that dephosphorylates AKT1 of the PI3K-AKT signalling pathway. We...
8.
Daddali R, Ojaniemi M, Hallman M, Ramet M, Haapalainen A
PLoS One
. 2020 Jun;
15(6):e0234403.
PMID: 32520951
MicroRNAs (miRNAs) are important regulators of gene expression, and their expression is associated with many physiological conditions. Here, we investigated potential associations between expression levels of miRNAs in human placenta...
9.
Tiensuu H, Haapalainen A, Karjalainen M, Pasanen A, Huusko J, Marttila R, et al.
PLoS Genet
. 2019 Jun;
15(6):e1008107.
PMID: 31194736
Spontaneous preterm birth (SPTB) is the leading cause of neonatal death and morbidity worldwide. Both maternal and fetal genetic factors likely contribute to SPTB. We performed a genome-wide association study...
10.
Haapalainen A, Karjalainen M, Daddali R, Ohlmeier S, Anttonen J, Maatta T, et al.
J Cell Mol Med
. 2017 Dec;
22(2):968-981.
PMID: 29193784
Understanding of timing of human parturition is incomplete. Therefore, we carried out proteomic analyses of full-term placentas from uncomplicated pregnancies to identify protein signatures associated with the onset of spontaneous...