Antti M Haapalainen
Overview
Explore the profile of Antti M Haapalainen including associated specialties, affiliations and a list of published articles.
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28
Citations
459
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Recent Articles
11.
Karjalainen M, Ojaniemi M, Haapalainen A, Mahlman M, Salminen A, Huusko J, et al.
J Immunol
. 2015 Jul;
195(5):2187-98.
PMID: 26209629
Spontaneous preterm birth (SPTB) is a major factor associating with deaths and with lowered quality of life in humans. Environmental and genetic factors influence the susceptibility. Previously, by analyzing families...
12.
Haapalainen A, Thomas K, Tyler P, Evans G, Almo S, Schramm V
Structure
. 2013 May;
21(6):963-74.
PMID: 23685211
Accumulation of 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) in bacteria disrupts the S-adenosylmethionine pool to alter biological methylations, synthesis of polyamines, and production of quorum-sensing molecules. Bacterial metabolism of MTA and...
13.
Suarez J, Haapalainen A, Cahill S, Ho M, Yan F, Almo S, et al.
Chem Biol
. 2013 Feb;
20(2):212-22.
PMID: 23438750
Purine nucleoside phosphorylase (PNP) is a target for leukemia, gout, and autoimmune disorders. Dynamic motion of catalytic site loops has been implicated in catalysis, but experimental evidence was lacking. We...
14.
Fukao T, Maruyama S, Ohura T, Hasegawa Y, Toyoshima M, Haapalainen A, et al.
JIMD Rep
. 2013 Feb;
3:107-15.
PMID: 23430882
Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency affects both isoleucine catabolism and ketone body metabolism. The disorder is characterized by intermittent ketoacidotic episodes. We report three Japanese patients. One patient (GK69) experienced...
15.
Thomas K, Haapalainen A, Burgos E, Evans G, Tyler P, Gulab S, et al.
Biochemistry
. 2012 Aug;
51(38):7541-50.
PMID: 22931458
5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) catalyzes the hydrolytic cleavage of adenine from methylthioadenosine (MTA). Inhibitor design and synthesis informed by transition state analysis have developed femtomolar inhibitors for MTANs, among the most...
16.
Wang S, Haapalainen A, Yan F, Du Q, Tyler P, Evans G, et al.
Biochemistry
. 2012 Aug;
51(35):6892-4.
PMID: 22891633
Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of...
17.
Mazet M, Harijan R, Kiema T, Haapalainen A, Morand P, Morales J, et al.
Int J Parasitol
. 2011 Sep;
41(12):1273-83.
PMID: 21907205
Thiolases are enzymes that remove an acetyl-coenzyme A group from acyl-CoA in the catabolic β-oxidation of fatty acids, or catalyse the reverse condensation reaction for anabolic processes such as the...
18.
Hiltunen J, Chen Z, Haapalainen A, Wierenga R, Kastaniotis A
Prog Lipid Res
. 2009 Aug;
49(1):27-45.
PMID: 19686777
The highly conserved fatty acid de novo synthesis pathway in mitochondria proceeds in an acyl carrier protein-dependent manner through a discrete set of enzymes. Saccharomyces cerevisiae has served as a...
19.
Nguyen V, Wallis K, Howard M, Haapalainen A, Salo K, Saaranen M, et al.
J Mol Biol
. 2008 Sep;
383(5):1144-55.
PMID: 18801374
Protein disulphide isomerase (PDI) is a key multi-domain protein folding catalyst in the endoplasmic reticulum. The b' domain of PDI is essential for the non-covalent binding of incompletely folded protein...
20.
Chen Z, Pudas R, Sharma S, Smart O, Juffer A, Hiltunen J, et al.
J Mol Biol
. 2008 May;
379(4):830-44.
PMID: 18479707
Structural and kinetic properties of the human 2-enoyl thioester reductase [mitochondrial enoyl-coenzyme A reductase (MECR)/ETR1] of the mitochondrial fatty acid synthesis (FAS) II pathway have been determined. The crystal structure...