Antonio Valencia
Overview
Explore the profile of Antonio Valencia including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
746
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Recent Articles
1.
Valencia A, Bieber V, Bajrami B, Marsh G, Hamann S, Wei R, et al.
Front Neurol
. 2021 Jul;
12:624051.
PMID: 34262517
Acetylation of tau protein is dysregulated in Alzheimer's Disease (AD). It has been proposed that acetylation of specific sites in the KXGS motif of tau can regulate phosphorylation of nearby...
2.
Valencia A, Sapp E, Kimm J, McClory H, Reeves P, Alexander J, et al.
Hum Mol Genet
. 2017 Oct;
26(21):4314.
PMID: 28973680
No abstract available.
3.
Valencia A, Sapp E, Kimm J, McClory H, Ansong K, Yohrling G, et al.
J Huntingtons Dis
. 2014 Apr;
2(4):459-75.
PMID: 24696705
Background: Synaptic connections are disrupted in patients with Huntington's disease (HD). Synaptosomes from postmortem brain are ideal for synaptic function studies because they are enriched in pre- and post-synaptic proteins...
4.
Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, et al.
Nat Neurosci
. 2013 Mar;
16(5):562-70.
PMID: 23525043
Huntington's disease is caused by expanded CAG repeats in HTT, conferring toxic gain of function on mutant HTT (mHTT) protein. Reducing mHTT amounts is postulated as a strategy for therapeutic...
5.
Valencia A, Sapp E, Kimm J, McClory H, Reeves P, Alexander J, et al.
Hum Mol Genet
. 2012 Dec;
22(6):1112-31.
PMID: 23223017
A mutation in the huntingtin (Htt) gene produces mutant Htt and Huntington's disease (HD), a neurodegenerative disorder. HD patients have oxidative damage in the brain, but the causes are unclear....
6.
Li X, Valencia A, McClory H, Sapp E, Kegel K, DiFiglia M
Biochem Biophys Res Commun
. 2012 May;
421(4):727-30.
PMID: 22542623
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Positron emission tomography studies have revealed a decline in glucose metabolism in...
7.
Ritch J, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey G, et al.
Mol Cell Neurosci
. 2012 Apr;
50(1):70-81.
PMID: 22508027
Neural stem (NS) cells are a limitless resource, and thus superior to primary neurons for drug discovery provided they exhibit appropriate disease phenotypes. Here we established NS cells for cellular...
8.
Sapp E, Valencia A, Li X, Aronin N, Kegel K, Vonsattel J, et al.
J Biol Chem
. 2012 Mar;
287(16):13487-99.
PMID: 22375012
Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length...
9.
Valencia A, Sapp E, Reeves P, Alexander J, Masso N, Li X, et al.
Neuroreport
. 2011 Nov;
23(1):10-5.
PMID: 22045254
Patients with Huntington's disease suffer severe neuronal loss and signs of oxidative damage in the brain. Previously we found that primary neurons from embryonic cortex of mice bearing the Huntington's...
10.
Kegel K, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, et al.
Mol Neurodegener
. 2010 Dec;
5:58.
PMID: 21156064
Background: The mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known...