Antonio J M Santos
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Explore the profile of Antonio J M Santos including associated specialties, affiliations and a list of published articles.
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15
Citations
685
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Recent Articles
1.
Mu Q, Ha A, Santos A, Lo Y, van Unen V, Miao Y, et al.
Dev Cell
. 2024 Nov;
60(3):342-351.e5.
PMID: 39579768
The rapidly regenerating intestinal epithelium requires crypt intestinal stem cells (ISCs). Wnt/β-catenin signaling maintains crypt homeostasis and Lgr5+ ISCs, and WNT ligands bind Frizzled receptors (FZD1-10). Identifying specific FZD(s) essential...
2.
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, et al.
Nature
. 2024 Jul;
632(8024):401-410.
PMID: 39048815
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is an autoimmune disease in which dietary...
3.
Choi S, van Unen V, Zhang H, Rustagi A, Alwahabi S, Santos A, et al.
Res Sq
. 2023 May;
PMID: 37205380
Tissue-resident immunity underlies essential host defenses against pathogens, but analysis in humans has lacked model systems where epithelial infection and accompanying resident immune cell responses can be observed . Indeed,...
4.
Salahudeen A, Choi S, Rustagi A, Zhu J, van Unen V, De la O S, et al.
Nature
. 2020 Nov;
588(7839):670-675.
PMID: 33238290
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial...
5.
Miao Y, Ha A, de Lau W, Yuki K, Santos A, You C, et al.
Cell Stem Cell
. 2020 Aug;
27(5):840-851.e6.
PMID: 32818433
Modulation of Wnt signaling has untapped potential in regenerative medicine due to its essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) cross-reactivity have hindered translational Wnt...
6.
Salahudeen A, Choi S, Rustagi A, Zhu J, De la O S, Flynn R, et al.
bioRxiv
. 2020 Aug;
PMID: 32743583
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange and is affected by disorders including interstitial lung disease, cancer, and SARS-CoV-2-associated COVID-19 pneumonia. Investigations of these localized...
7.
Santos A, Lo Y, Mah A, Kuo C
Trends Cell Biol
. 2018 Sep;
28(12):1062-1078.
PMID: 30195922
The intestinal epithelium is a rapidly renewing cellular compartment. This constant regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance between intestinal stem cell (ISC) proliferation...
8.
Santos A, Boucrot E
Methods Mol Biol
. 2018 Aug;
1847:23-35.
PMID: 30129007
Endocytosis mediates the cellular uptake of nutrients, modulates signaling by regulating levels of cell surface receptors, and is usurped by pathogens during infection. Endocytosis activity is known to vary during...
9.
Santos A, Durkin C, Helaine S, Boucrot E, Holden D
Infect Immun
. 2016 May;
84(7):2149-2158.
PMID: 27185791
Several bacterial pathogens and viruses interfere with the cell cycle of their host cells to enhance virulence. This is especially apparent in bacteria that colonize the gut epithelium, where inhibition...
10.
Santos A, Nogueira C, Ortega-Bellido M, Malhotra V
J Cell Biol
. 2016 May;
213(3):343-54.
PMID: 27138255
Procollagens, pre-chylomicrons, and pre-very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We have...