Antonio Dominguez-Meijide
Overview
Explore the profile of Antonio Dominguez-Meijide including associated specialties, affiliations and a list of published articles.
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27
Citations
617
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Recent Articles
11.
Bras I, Dominguez-Meijide A, Gerhardt E, Koss D, Lazaro D, Santos P, et al.
J Neurochem
. 2020 Jan;
153(4):433-454.
PMID: 31957016
Synucleinopathies are a group of disorders characterized by the accumulation of inclusions rich in the a-synuclein (aSyn) protein. This group of disorders includes Parkinson's disease, dementia with Lewy bodies (DLB),...
12.
Szego E, Dominguez-Meijide A, Gerhardt E, Konig A, Koss D, Li W, et al.
Cell Rep
. 2019 Jul;
28(1):65-77.e6.
PMID: 31269451
Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the molecular mechanisms leading to disease are unclear. We identify the 10 kDa heat shock protein (HSP10) as a mediator of...
13.
Vasili E, Dominguez-Meijide A, Outeiro T
Front Mol Neurosci
. 2019 May;
12:107.
PMID: 31105524
Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) and tau, respectively. The coexistence of aSyn and tau aggregates...
14.
Outeiro T, Harvey K, Dominguez-Meijide A, Gerhardt E
Biochem Soc Trans
. 2019 May;
47(3):827-838.
PMID: 31085616
The identification of genetic forms of Parkinson's disease (PD) has tremendously expanded our understanding of the players and mechanisms involved. Mutations in the genes encoding for alpha-synuclein (aSyn), LRRK2, and...
15.
Chiang A, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried J, Mazzone C, et al.
Bioorg Med Chem
. 2018 Dec;
27(1):79-91.
PMID: 30528127
Over-expression of the Hsp70 molecular chaperone prevents protein aggregation and ameliorates neurodegenerative disease phenotypes in model systems. We identified an Hsp70 activator, MAL1-271, that reduces α-synuclein aggregation in a Parkinson's...
16.
Diaz-Ruiz C, Villar-Cheda B, Dominguez-Meijide A, Garrido-Gil P, Guerra M, Labandeira-Garcia J
J Gerontol A Biol Sci Med Sci
. 2018 Nov;
75(3):416-424.
PMID: 30412227
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the...
17.
Garrido-Gil P, Dominguez-Meijide A, Moratalla R, Guerra M, Labandeira-Garcia J
Oncotarget
. 2018 Mar;
9(13):10834-10846.
PMID: 29541380
Gastrointestinal dysfunction is a common problem in the elderly. Aging-related changes in interactions between local dopaminergic and renin-angiotensin systems (RAS) have been observed in the brain, renal and vascular tissues....
18.
Garrido-Gil P, Rodriguez-Perez A, Dominguez-Meijide A, Guerra M, Labandeira-Garcia J
Mol Neurobiol
. 2018 Feb;
55(9):7297-7316.
PMID: 29404956
The exact mechanism of gut dysfunction in Parkinson's disease and, conversely, the role of gut pathology in brain dopaminergic degeneration are controversial. We investigated the effects of nigral lesions on...
19.
Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures
Dominguez-Meijide A, Rodriguez-Perez A, Diaz-Ruiz C, Guerra M, Labandeira-Garcia J
Brain Behav Immun
. 2017 Feb;
62:277-290.
PMID: 28232171
Dopamine is an immunomodulatory molecule that acts on immune effector cells both in the CNS and peripheral tissues. However, the role of changes in dopamine levels in the neuroinflammatory response...
20.
Labandeira-Garcia J, Rodriguez-Perez A, Villar-Cheda B, Borrajo A, Dominguez-Meijide A, Guerra M
Neuroscientist
. 2014 Oct;
21(6):616-29.
PMID: 25323761
The small GTP-binding protein Rho plays an important role in several cellular functions. RhoA, which is a member of the Rho family, initiates cellular processes that act on its direct...