Antonella Consiglio
Overview
Explore the profile of Antonella Consiglio including associated specialties, affiliations and a list of published articles.
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50
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6272
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Recent Articles
1.
Hu H, Serra C, Zhang W, Scrivo A, Fernandez-Carasa I, Consiglio A, et al.
Cell Chem Biol
. 2024 Feb;
31(5):973-988.e4.
PMID: 38335967
The (poly)pharmacology of drug metabolites is seldom comprehensively characterized in drug discovery. However, some drug metabolites can reach high plasma concentrations and display in vivo activity. Here, we use computational...
2.
Pons-Espinal M, Blasco-Agell L, Fernandez-Carasa I, Andres-Benito P, di Domenico A, Richaud-Patin Y, et al.
JCI Insight
. 2024 Feb;
9(3).
PMID: 38329129
Parkinson's disease (PD) is a neurodegenerative disease associated with progressive death of midbrain dopamine (DAn) neurons in the substantia nigra (SN). Since it has been proposed that patients with PD...
3.
Jung-Kc K, Tristan-Noguero A, Altankhuyag A, Pinol Belenguer D, Prestegard K, Fernandez-Carasa I, et al.
J Inherit Metab Dis
. 2024 Jan;
47(3):494-508.
PMID: 38196161
Proteostatic regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase...
4.
Soler-Vazquez M, Romero M, Todorcevic M, Delgado K, Calatayud C, Benitez-Amaro A, et al.
Metab Eng
. 2023 Apr;
77:256-272.
PMID: 37088334
Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of...
5.
Tristan-Noguero A, Fernandez-Carasa I, Calatayud C, Bermejo-Casadesus C, Pons-Espinal M, Colini Baldeschi A, et al.
EMBO Mol Med
. 2023 Feb;
15(3):e15847.
PMID: 36740977
Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder leading to dopaminergic depletion and early-onset Parkinsonism. Affected children present with either a severe form that does not respond to L-Dopa...
6.
Ferrer-Lorente R, Lozano-Cruz T, Fernandez-Carasa I, Milowska K, de la Mata F, Bryszewska M, et al.
Biomacromolecules
. 2021 Oct;
22(11):4582-4591.
PMID: 34613701
Accumulation of misfolded α-synuclein (α-syn) is a hallmark of Parkinson's disease (PD) thought to play important roles in the pathophysiology of the disease. Dendritic systems, able to modulate the folding...
7.
Defterali C, Moreno-Estelles M, Crespo C, Diaz-Guerra E, Diaz-Moreno M, Vergano-Vera E, et al.
Stem Cells
. 2021 May;
39(9):1253-1269.
PMID: 33963799
Although previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been little...
8.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
9.
Pons-Espinal M, Blasco-Agell L, Consiglio A
Cell Mol Life Sci
. 2020 Nov;
78(5):2081-2094.
PMID: 33210214
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic movement impairments that are caused by the progressive loss of dopamine-containing neurons (DAn) within the substantia nigra pars compacta....
10.
Cai R, Zhang Y, Simmering J, Schultz J, Li Y, Fernandez-Carasa I, et al.
J Clin Invest
. 2019 Sep;
129(10):4539-4549.
PMID: 31524631
Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed...