Anton Safonov
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Explore the profile of Anton Safonov including associated specialties, affiliations and a list of published articles.
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25
Citations
604
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Recent Articles
11.
Gupta A, Gazzo A, Selenica P, Safonov A, Pareja F, da Silva E, et al.
bioRxiv
. 2024 May;
PMID: 38746158
Acquired genetic alterations commonly drive resistance to endocrine and targeted therapies in metastatic breast cancer , however the underlying processes engendering these diverse alterations are largely uncharacterized. To identify the...
12.
Ward A, Farengo-Clark D, McKenna D, Safonov A, Good M, Le A, et al.
Cancer Genet
. 2024 Apr;
284-285:43-47.
PMID: 38677009
Background: Germline heterozygous TP53 pathogenic variants (PVs) cause Li Fraumeni Syndrome (LFS, OMIM#151623). TP53 PVs at lower-than-expected variant allele frequencies (VAF) may reflect postzygotic mosaicism (PZM) or clonal hematopoiesis (CH);...
13.
Kim S, Armand J, Safonov A, Zhang M, Soni R, Schwartz G, et al.
Cell Rep
. 2023 Oct;
42(11):113198.
PMID: 37865915
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are key therapeutic agents in the management of metastatic hormone-receptor-positive breast cancer. However, the emergence of drug resistance limits their long-term efficacy. Here,...
14.
Safonov A, Nomakuchi T, Chao E, Horton C, Dolinsky J, Yussuf A, et al.
medRxiv
. 2023 Aug;
PMID: 37609227
Loss of function variants in the gene cause neurofibromatosis type 1 (NF1), a genetic disorder characterized by complete penetrance, prevalence of 1 in 3,000, characteristic physical exam findings, and a...
15.
Arora K, Tran T, Kemel Y, Mehine M, Liu Y, Nandakumar S, et al.
Cancer Discov
. 2022 Sep;
12(11):2552-2565.
PMID: 36048199
Significance: We performed a comprehensive analysis of ancestral associations with somatic mutations in a real-world pan-cancer cohort, including >5,000 non-European individuals. Using an FDA-authorized tumor sequencing panel and an FDA-recognized...
16.
Nguyen B, Fong C, Luthra A, Smith S, DiNatale R, Nandakumar S, et al.
Cell
. 2022 Feb;
185(3):563-575.e11.
PMID: 35120664
Metastatic progression is the main cause of death in cancer patients, whereas the underlying genomic mechanisms driving metastasis remain largely unknown. Here, we assembled MSK-MET, a pan-cancer cohort of over...
17.
Smith A, Ferraro E, Safonov A, Bernado Morales C, Lahuerta E, Li Q, et al.
Nat Commun
. 2021 Nov;
12(1):6667.
PMID: 34795269
Inhibition of HER2 in HER2-amplified breast cancer has been remarkably successful clinically, as demonstrated by the efficacy of HER-kinase inhibitors and HER2-antibody treatments. Whilst resistance to HER2 inhibition is common...
18.
Bolton K, Koh Y, Foote M, Im H, Jee J, Sun C, et al.
Nat Commun
. 2021 Oct;
12(1):5975.
PMID: 34645798
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These...
19.
Bolton K, Koh Y, Foote M, Im H, Jee J, Sun C, et al.
medRxiv
. 2020 Dec;
PMID: 33269365
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These...
20.
Abu-Khalaf M, Safonov A, Stratton J, Wang S, Hatzis C, Park E, et al.
Breast Cancer Res Treat
. 2019 Apr;
176(2):261-270.
PMID: 31020471
Background: There is a lack of consensus to guide which breast cancer patients require left ventricular function assessment (LVEF) prior to anthracycline therapy; the cost-effectiveness of screening this patient population...