Antoine E Karnoub
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Explore the profile of Antoine E Karnoub including associated specialties, affiliations and a list of published articles.
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35
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3421
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Recent Articles
1.
Tu Z, Bassal M, Bell G, Zhang Y, Hu Y, Quintana L, et al.
Mol Cell
. 2024 Oct;
84(21):4209-4223.e6.
PMID: 39481384
Transposable elements (TEs) are indispensable for human development, with critical functions in pluripotency and embryogenesis. TE sequences also contribute to human pathologies, especially cancer, with documented activities as cis/trans transcriptional...
2.
Huang D, Tu Z, Karnoub A, Wei W, Rezaeian A
Biomedicines
. 2024 Oct;
12(10).
PMID: 39457533
: Busulfan is an FDA-approved alkylating drug used in the chemotherapy of advanced acute myeloid leukemia. The precise mechanisms by which Busulfan kills spermatogonia stem cells (SSCs) are not yet...
3.
Zhang T, Xu D, Liu J, Wang M, Duan L, Liu M, et al.
Nat Cell Biol
. 2023 Jul;
25(7):950-962.
PMID: 37400498
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN-pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RIPK1, a known...
4.
Tu Z, Hu Y, Raizada D, Bassal M, Tenen D, Karnoub A
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2203180119.
PMID: 36269860
The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive tumor subtype encompassing ∼15% of breast cancers and which possesses no...
5.
Tu Z, Karnoub A
Semin Cancer Biol
. 2022 Sep;
86(Pt 2):81-92.
PMID: 36087857
Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body. They are endowed with capacities to differentiate into multiple connective...
6.
Tu Z, Karnoub A
STAR Protoc
. 2022 May;
3(2):101413.
PMID: 35634360
We provide a protocol for gain-of-function (GOF) cDNA screen of genes that foster cancer cell colonization of secondary tissues, the last and most lethal step of the metastasis cascade. We...
7.
Zheng Y, Karnoub A
Mol Cell Endocrinol
. 2021 Jul;
535:111374.
PMID: 34242715
Cancer cells within breast tumors exist within a hierarchy in which only a small and rare subset of cells is able to regenerate growths with the heterogeneity of the original...
8.
Tu Z, Schmoellerl J, Mariani O, Zheng Y, Hu Y, Vincent-Salomon A, et al.
NPJ Breast Cancer
. 2021 Jun;
7(1):69.
PMID: 34059683
The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promote TNBC progression by activating...
9.
Tu Z, Hou S, Zheng Y, Abuduli M, Onder T, Intlekofer A, et al.
iScience
. 2021 May;
24(5):102425.
PMID: 34036247
Elucidations of the factors that promote the growth of disseminated tumor cells (DTCs) into life-threatening lesions stand to provide much needed prognostic and therapeutic targets of translational utility for patients...
10.
Amey C, Karnoub A
Oncol Hematol Rev
. 2021 May;
13(1):45-55.
PMID: 33959299
Metastasis is often accompanied by radio- and chemotherapeutic resistance to anticancer treatments and is the major cause of death in cancer patients. Better understanding of how cancer cells circumvent therapeutic...