Antje Hufner
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Explore the profile of Antje Hufner including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
157
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Recent Articles
1.
Kretschmer N, Durchschein C, Hufner A, Rinner B, Lohberger B, Bauer R
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628494
Melanoma is a complex and heterogenous disease, displays the deadliest form of skin cancer, and accounts for approx. 80% of all skin cancer deaths. In this study, we reported on...
2.
Kretschmer N, Hufner A, Durchschein C, Popodi K, Rinner B, Lohberger B, et al.
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33803437
Melanoma is the deadliest form of skin cancer and accounts for about three quarters of all skin cancer deaths. Especially at an advanced stage, its treatment is challenging, and survival...
3.
Durchschein C, Hufner A, Rinner B, Stallinger A, Deutsch A, Lohberger B, et al.
Molecules
. 2018 Nov;
23(11).
PMID: 30380765
Despite much research in the last centuries, treatment of malignant melanoma is still challenging because of its mostly unnoticeable metastatic spreading and aggressive growth rate. Therefore, the discovery of novel...
4.
Stout K, Bernaskova M, Miller G, Hufner A, Schuehly W
Molecules
. 2018 Oct;
23(10).
PMID: 30287800
In traditional Asian medicinal systems, preparations of the root and stem bark of species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignans honokiol and magnolol...
5.
Bernaskova M, Schoeffmann A, Schuehly W, Hufner A, Baburin I, Hering S
Bioorg Med Chem
. 2015 Sep;
23(20):6757-62.
PMID: 26410663
In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignan honokiol together...
6.
Wube A, Hufner A, Seebacher W, Kaiser M, Brun R, Bauer R, et al.
Molecules
. 2014 Sep;
19(9):14204-20.
PMID: 25211002
A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against...
7.
Wube A, Guzman J, Hufner A, Hochfellner C, Blunder M, Bauer R, et al.
Molecules
. 2012 Jul;
17(7):8217-40.
PMID: 22777190
To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some N-alkyl-4-(1H)-quinolones bearing position 2 alkynyls with various chain length and...
8.
Guzman J, Wube A, Evangelopoulos D, Gupta A, Hufner A, Basavannacharya C, et al.
J Antimicrob Chemother
. 2011 May;
66(8):1766-72.
PMID: 21622974
Objectives: The aim of this study was to comprehensively evaluate the antibacterial activity and MurE inhibition of a set of N-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria. Methods:...
9.
Wube A, Bucar F, Hochfellner C, Blunder M, Bauer R, Hufner A
Eur J Med Chem
. 2011 Mar;
46(6):2091-101.
PMID: 21429630
In an effort to improve biological activities and to examine antimycobacterial-lipophilicity relationships of 2-[(1E)-alkenyl)]-4-(1H)-quinolones, we have synthesized a series of 30 quinolones by introducing several alkyl groups, an alkenyl and...
10.
Bohmdorfer M, Maier-Salamon A, Taferner B, Reznicek G, Thalhammer T, Hering S, et al.
J Pharm Sci
. 2011 Mar;
100(8):3506-3516.
PMID: 21404278
The biotransformation of honokiol, a major constituent of the bark of Magnolia officinalis, was investigated in rat and human livers. When isolated, rat livers were perfused with 10 µM honokiol...