Ansi Chang
Overview
Explore the profile of Ansi Chang including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
2378
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Recent Articles
1.
Trapp B, Vignos M, Dudman J, Chang A, Fisher E, Staugaitis S, et al.
Lancet Neurol
. 2018 Aug;
17(10):870-884.
PMID: 30143361
Background: Demyelination of cerebral white matter is thought to drive neuronal degeneration and permanent neurological disability in individuals with multiple sclerosis. Findings from brain MRI studies, however, support the possibility...
2.
Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt J, et al.
Cell Rep
. 2015 Mar;
10(11):1836-49.
PMID: 25801023
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS,...
3.
Dutta R, Chomyk A, Chang A, Ribaudo M, Deckard S, Doud M, et al.
Ann Neurol
. 2013 Apr;
73(5):637-45.
PMID: 23595422
Objective: Hippocampal demyelination, a common feature of postmortem multiple sclerosis (MS) brains, reduces neuronal gene expression and is a likely contributor to the memory impairment that is found in >40%...
4.
Chen J, Easley K, Schneider C, Nakamura K, Kidd G, Chang A, et al.
Neurology
. 2012 Dec;
80(3):246-52.
PMID: 23269598
Objective: Presently there is no clinically feasible imaging modality that can effectively detect cortical demyelination in patients with multiple sclerosis (MS). The objective of this study is to determine if...
5.
Chang A, Staugaitis S, Dutta R, Batt C, Easley K, Chomyk A, et al.
Ann Neurol
. 2012 Oct;
72(6):918-26.
PMID: 23076662
Objective: Generation and differentiation of new oligodendrocytes in demyelinated white matter is the best described repair process in the adult human brain. However, remyelinating capacity falters with age in patients...
6.
Moll N, Rietsch A, Thomas S, Ransohoff A, Lee J, Fox R, et al.
Ann Neurol
. 2011 Dec;
70(5):764-73.
PMID: 22162059
Objective: The study was undertaken to determine the pathologic basis of subtle abnormalities in magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) parameters observed in normal-appearing white matter (NAWM)...
7.
Dutta R, Chang A, Doud M, Kidd G, Ribaudo M, Young E, et al.
Ann Neurol
. 2011 Mar;
69(3):445-54.
PMID: 21446020
Objective: Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system. Although the clinical impact of gray matter pathology in MS brains is unknown, 30 to...
8.
Wu C, Chang A, Smith M, Won R, Yin X, Staugaitis S, et al.
J Neurosci
. 2009 Jun;
29(24):7649-57.
PMID: 19535576
We have identified a novel population of cells in the subventricular zone (SVZ) of the mammalian brain that expresses beta4 tubulin (betaT4) and has properties of primitive neuroectodermal cells. betaT4...
9.
Moll N, Cossoy M, Fisher E, Staugaitis S, Tucky B, Rietsch A, et al.
Arch Neurol
. 2009 Jan;
66(1):44-53.
PMID: 19139298
Objective: To compare leukocyte accumulation and expression of the chemokine receptor/ligand pair CXCR4/CXCL12 in magnetic resonance imaging-defined regions of interest (ROIs) in brains from patients with chronic multiple sclerosis. We...
10.
Chang A, Smith M, Yin X, Fox R, Staugaitis S, Trapp B
Brain
. 2008 Aug;
131(Pt 9):2366-75.
PMID: 18669500
Subcortical white matter in the adult human brain contains a population of interneurons that helps regulate cerebral blood flow. We investigated the fate of these neurons following subcortical white matter...