Anshul Bhardwaj
Overview
Explore the profile of Anshul Bhardwaj including associated specialties, affiliations and a list of published articles.
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43
Citations
576
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Recent Articles
11.
Mylod E, McKenna E, Davern M, Barr M, Donlon N, Bibby B, et al.
Clin Exp Med
. 2022 Apr;
23(2):411-425.
PMID: 35364779
The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this...
12.
Donlon N, Davern M, Sheppard A, OConnell F, Dunne M, Hayes C, et al.
Front Immunol
. 2022 Feb;
13:823225.
PMID: 35154142
Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains...
13.
Heeran A, McCready J, Dunne M, Donlon N, Nugent T, Bhardwaj A, et al.
Metabolites
. 2021 Nov;
11(11).
PMID: 34822426
Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying...
14.
Donlon N, Davern M, Sheppard A, Power R, OConnell F, Heeran A, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439160
Response rates to the current gold standards of care for treating oesophageal adenocarcinoma (OAC) remain modest with 15-25% of patients achieving meaningful pathological responses, highlighting the need for novel therapeutic...
15.
Mylod E, Melo A, Donlon N, Davern M, Bhardwaj A, Reynolds J, et al.
J Immunol
. 2021 Jul;
207(4):1200-1210.
PMID: 34321227
Esophagogastric adenocarcinomas (EAC) are obesity-associated malignancies underpinned by severe immune dysregulation and inflammation. Our previous work indicates that NK cells migrate to EAC omentum, where they undergo phenotypic and functional...
16.
Melo A, Mylod E, Fitzgerald V, Donlon N, Murphy D, Foley E, et al.
Clin Immunol
. 2021 Jul;
229:108797.
PMID: 34273585
The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and...
17.
Davern M, Donlon N, Sheppard A, O Connell F, Hayes C, Bhardwaj A, et al.
Transl Oncol
. 2021 Mar;
14(6):101062.
PMID: 33765543
Use of immune checkpoint inhibitors (ICIs) with chemotherapy to enhance responses in oesophageal adenocarcinoma (OAC) is an attractive approach. We identified subpopulations of OAC cells expressing inhibitory immune checkpoint (IC)...
18.
Komolov K, Sulon S, Bhardwaj A, van Keulen S, Duc N, Laurinavichyute D, et al.
Mol Cell
. 2020 Dec;
81(2):323-339.e11.
PMID: 33321095
The phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) facilitates arrestin binding and receptor desensitization. Although this process can be regulated by Ca-binding proteins such as calmodulin (CaM)...
19.
Donlon N, Sheppard A, Davern M, OConnell F, Phelan J, Power R, et al.
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33202734
Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority...
20.
Yoo S, Bhardwaj A, Benovic J
Trends Pharmacol Sci
. 2020 May;
41(6):387-389.
PMID: 32362341
The ability to design 'biased' drugs that selectively activate G protein-coupled receptor (GPCR) signaling pathways beneficial in treating a disease, while limiting their side effects, is of broad significance. Lee...