Annette N Ratcliff
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Explore the profile of Annette N Ratcliff including associated specialties, affiliations and a list of published articles.
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7
Citations
176
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Recent Articles
1.
Ratcliff A, Venner C, Olabode A, Knapp J, Pankrac J, Derecichei I, et al.
J Virol
. 2022 Jul;
96(14):e0185121.
PMID: 35862673
A rare but natural polymorphism in the HIV-1 envelope (Env) glycoprotein, lysine at position 425 was selected as a mutation conferring resistance to maraviroc (MVC) . N425K has not been...
2.
Klein K, Nankya I, Nickel G, Ratcliff A, Meadows A, Hathaway N, et al.
J Virol
. 2020 Nov;
95(3).
PMID: 33177204
Exposure of the genital mucosa to a genetically diverse viral swarm from the donor HIV-1 can result in breakthrough and systemic infection by a single transmitted/founder (TF) virus in the...
3.
Kulkarni M, Ratcliff A, Bhat M, Alwarawrah Y, Hughes P, Arcos J, et al.
Retrovirology
. 2017 Oct;
14(1):45.
PMID: 28962653
Background: Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and...
4.
Alwarawrah Y, Hughes P, Loiselle D, Carlson D, Darr D, Jordan J, et al.
Cell Chem Biol
. 2016 Jun;
23(6):678-88.
PMID: 27265747
Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is...
5.
Multifaceted mechanisms of HIV inhibition and resistance to CCR5 inhibitors PSC-RANTES and Maraviroc
Lobritz M, Ratcliff A, Marozsan A, Dudley D, Tilton J, Arts E
Antimicrob Agents Chemother
. 2013 Mar;
57(6):2640-50.
PMID: 23529732
Small-molecule CCR5 antagonists, such as maraviroc (MVC), likely block HIV-1 through an allosteric, noncompetitive inhibition mechanism, whereas inhibition by agonists such as PSC-RANTES is less defined and may involve receptor...
6.
Ratcliff A, Shi W, Arts E
J Virol
. 2012 Nov;
87(2):923-34.
PMID: 23135713
Maraviroc (MVC) is a CCR5 antagonist that inhibits HIV-1 entry by binding to the coreceptor and inducing structural alterations in the extracellular loops. In this study, we isolated MVC-resistant variants...
7.
Lobritz M, Ratcliff A, Arts E
Viruses
. 2011 Oct;
2(5):1069-1105.
PMID: 21994672
Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this...