Manjusha M Kulkarni
Overview
Explore the profile of Manjusha M Kulkarni including associated specialties, affiliations and a list of published articles.
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15
Citations
366
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Recent Articles
1.
Fodor A, Hess C, Ganas P, Boros Z, Kiss J, Makrai L, et al.
Antibiotics (Basel)
. 2023 Sep;
12(9).
PMID: 37760758
Anti-microbial peptides provide a powerful toolkit for combating multidrug resistance. Combating eukaryotic pathogens is complicated because the intracellular drug targets in the eukaryotic pathogen are frequently homologs of cellular structures...
2.
Scarneo S, Smith A, Favret J, OConnell R, Pickeral J, Yang K, et al.
Sci Rep
. 2022 Oct;
12(1):18091.
PMID: 36302951
Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified...
3.
Kulkarni M, Ratcliff A, Bhat M, Alwarawrah Y, Hughes P, Arcos J, et al.
Retrovirology
. 2017 Oct;
14(1):45.
PMID: 28962653
Background: Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and...
4.
Alwarawrah Y, Hughes P, Loiselle D, Carlson D, Darr D, Jordan J, et al.
Cell Chem Biol
. 2016 Jun;
23(6):678-88.
PMID: 27265747
Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is...
5.
Keim S, Kulkarni M, McNamara K, Geraghty S, Billock R, Ronau R, et al.
Pediatrics
. 2015 Apr;
135(5):e1157-62.
PMID: 25847797
Background: The US Food and Drug Administration recommends against feeding infants human milk from unscreened donors, but sharing milk via the Internet is growing in popularity. Recipient infants risk the...
6.
Kulkarni M, Varikuti S, Terrazas C, Kimble J, Satoskar A, McGwire B
Immunology
. 2014 Dec;
145(2):225-31.
PMID: 25545325
The control of Trypanosoma cruzi infection is related to interferon-γ (IFN-γ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 (STAT-1) is...
7.
Kulkarni M, Karafova A, Kamysz W, McGwire B
Parasitol Res
. 2014 Mar;
113(5):1971-6.
PMID: 24658630
Antimicrobial peptides are increasingly being explored as alternative agents for therapy against the parasitic protozoan Leishmania. Previously, we reported that the synthetic magainin analog, pexiganan, induced apoptosis of surface protease-deficient...
8.
Kulkarni M, Reddy N, Gude T, McGwire B
Parasitol Res
. 2013 Feb;
112(5):2095-9.
PMID: 23392902
The digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with fluconazole and ketoconazole against cutaneous...
9.
Kulkarni M, Karafova A, Kamysz W, Schenkman S, Pelle R, McGwire B
J Biol Chem
. 2013 Feb;
288(12):8772-8784.
PMID: 23386612
The mechanisms by which Trypanosoma cruzi survives antimicrobial peptides and differentiates during its transit through the gastrointestinal tract of the reduviid vector are unknown. We show that cyclophilin, a peptidyl-prolyl...
10.
Kulkarni M, Barbi J, McMaster W, Gallo R, Satoskar A, McGwire B
Cell Microbiol
. 2011 Apr;
13(6):913-23.
PMID: 21501359
Cathelicidin-type antimicrobial peptides (CAMP) are important mediators of innate immunity against microbial pathogens acting through direct interaction with and disruption of microbial membranes and indirectly through modulation of host cell...