Annette N Chiang
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Explore the profile of Annette N Chiang including associated specialties, affiliations and a list of published articles.
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6
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360
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Recent Articles
1.
Goeckeler-Fried J, Aldrin Denny R, Joshi D, Hill C, Larsen M, Chiang A, et al.
Bioorg Med Chem Lett
. 2021 Jul;
48:128243.
PMID: 34246753
A growing number of diseases are linked to the misfolding of integral membrane proteins, and many of these proteins are targeted for ubiquitin-proteasome-dependent degradation. One such substrate is a mutant...
2.
Chiang A, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried J, Mazzone C, et al.
Bioorg Med Chem
. 2018 Dec;
27(1):79-91.
PMID: 30528127
Over-expression of the Hsp70 molecular chaperone prevents protein aggregation and ameliorates neurodegenerative disease phenotypes in model systems. We identified an Hsp70 activator, MAL1-271, that reduces α-synuclein aggregation in a Parkinson's...
3.
Veit G, Avramescu R, Chiang A, Houck S, Cai Z, Peters K, et al.
Mol Biol Cell
. 2016 Jan;
27(3):424-33.
PMID: 26823392
More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been described that confer a range of molecular cell biological and functional phenotypes. Most of these mutations...
4.
Bell S, Chiang A, Brodsky J
PLoS One
. 2011 Jun;
6(5):e20047.
PMID: 21625512
Plasmodium falciparum causes the most virulent form of malaria and encodes a large number of molecular chaperones. Because the parasite encounters radically different environments during its lifecycle, many members of...
5.
Botha M, Chiang A, Needham P, Stephens L, Hoppe H, Kulzer S, et al.
Cell Stress Chaperones
. 2010 Dec;
16(4):389-401.
PMID: 21191678
Heat shock protein 70 (Hsp70) and heat shock protein 40 (Hsp40) function as molecular chaperones during the folding and trafficking of proteins within most cell types. However, the Hsp70-Hsp40 chaperone...
6.
Chiang A, Valderramos J, Balachandran R, Chovatiya R, Mead B, Schneider C, et al.
Bioorg Med Chem
. 2009 Feb;
17(4):1527-33.
PMID: 19195901
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle. In...