Anne Cucchiarini
Overview
Explore the profile of Anne Cucchiarini including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
47
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0
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Recent Articles
1.
Perez-Soto M, Ramos-Soriano J, Penalver P, Belmonte-Reche E, OHagan M, Cucchiarini A, et al.
Eur J Med Chem
. 2024 Jul;
276:116641.
PMID: 38971047
Chagas disease is caused by the parasite Trypanosoma cruzi and affects over 7 million people worldwide. The two actual treatments, Benznidazole (Bzn) and Nifurtimox, cause serious side effects due to...
2.
Mehrdad S, Cucchiarini A, Mergny J, Kazemi Noureini S
Biochimie
. 2024 May;
225:146-155.
PMID: 38821199
The industrial world exposes living organisms to a variety of metal pollutants. Here we investigated whether such elements affect G-rich sequences susceptible to fold into G-quadruplex (GQ) structures. Thermal stability...
3.
Brazda V, Sislerova L, Cucchiarini A, Mergny J
NAR Genom Bioinform
. 2024 May;
6(2):lqae060.
PMID: 38817800
Current methods of processing archaeological samples combined with advances in sequencing methods lead to disclosure of a large part of and Denisovans genetic information. It is hardly surprising that the...
4.
Miranda A, Cucchiarini A, Esnault C, Andrau J, Oliveira P, Mergny J, et al.
Int J Biol Macromol
. 2024 May;
270(Pt 1):132244.
PMID: 38729459
To combat cancer, a comprehensive understanding of the molecular mechanisms and behaviors involved in carcinogenesis is crucial, as tumorigenesis is a complex process influenced by various genetic events and disease...
5.
Bhatt U, Cucchiarini A, Luo Y, Evans C, Mergny J, Iyer K, et al.
Genome Res
. 2024 Feb;
34(2):217-230.
PMID: 38355305
Secondary structure is a principal determinant of lncRNA function, predominantly regarding scaffold formation and interfaces with target molecules. Noncanonical secondary structures that form in nucleic acids have known roles in...
6.
Gajarsky M, Stadlbauer P, Sponer J, Cucchiarini A, Dobrovolna M, Brazda V, et al.
Angew Chem Int Ed Engl
. 2023 Dec;
63(7):e202313226.
PMID: 38143239
DNA quadruplex structures provide an additional layer of regulatory control in genome maintenance and gene expression and are widely used in nanotechnology. We report the discovery of an unprecedented tetrastranded...
7.
Fazelifar P, Cucchiarini A, Khoshbin Z, Mergny J, Kazemi Noureini S
J Biomol Struct Dyn
. 2023 Dec;
43(4):1674-1688.
PMID: 38100552
G-rich sequences have the potential to fold into G-quadruplexes (GQs). G-quadruplexes, particularly those positioned in the regulatory regions of proto-oncogenes, have recently garnered attention in anti-cancer drug design. A thermal...
8.
Saad M, Zhang R, Cucchiarini A, Mehawej C, Mergny J, Mroueh M, et al.
Biochimie
. 2023 Sep;
214(Pt A):45-56.
PMID: 37660977
The majority of drugs are metabolized by cytochrome P450 (CYP) enzymes, primarily belonging to the CYP1, CYP2 and CYP3 families. Genetic variations are the main cause of inter-individual differences in...
9.
Esnault C, Magat T, El Aabidine A, Garcia-Oliver E, Cucchiarini A, Bouchouika S, et al.
Nat Genet
. 2023 Jul;
55(8):1359-1369.
PMID: 37400615
Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence G4s associated with open chromatin via nuclease...
10.
Luo Y, Granzhan A, Marquevielle J, Cucchiarini A, Lacroix L, Amrane S, et al.
Biochimie
. 2023 Jan;
214(Pt A):5-23.
PMID: 36596406
Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate crucial biological activities. Among these oddities, guanine-rich DNA sequences can form unusual four-stranded secondary structures called G-quadruplexes (G4s). G4-prone sequences...