Jean-Louis Mergny
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Explore the profile of Jean-Louis Mergny including associated specialties, affiliations and a list of published articles.
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276
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7667
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Recent Articles
1.
Wei S, Zhang X, Feng Y, Tao S, Qiu D, Yan X, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40047376
G-quadruplexes (G4s) are challenging targets for chemical biology interventions, notably because of their dynamic topological polymorphism. We found that the antibiotic small- molecule colistin (COL) interacts specifically with a single...
2.
Alves A, Miranda A, Zanin I, Richter S, Mergny J, Cruz C
Int J Biol Macromol
. 2025 Jan;
296:139582.
PMID: 39798757
Understanding the mechanisms of carcinogenesis is essential to combat cancer. The search for alternative targets for anticancer therapy has gained interest, particularly when focused on upstream pathways. This strategy is...
3.
Kledus F, Dobrovolna M, Mergny J, Brazda V
Sci Rep
. 2025 Jan;
15(1):76.
PMID: 39747944
Retroviruses are among the most extensively studied viral families, both historically and in contemporary research. They are primarily investigated in the fields of viral oncogenesis, reverse transcription mechanisms, and other...
4.
Xia J, Chen J, Zhou J, Cheng M, Zhuang X, Cai C, et al.
J Phys Chem B
. 2024 Nov;
128(45):11077-11087.
PMID: 39498768
G-quadruplexes (G4s) are four-stranded structures formed by guanine-rich sequences. While their structures, properties, and applications have been extensively studied, an understanding of their folding processes remains limited. In this study,...
5.
Basu P, Kejnovska I, Gajarsky M, Subert D, Mikesova T, Renciuk D, et al.
Nucleic Acids Res
. 2024 Nov;
52(21):13224-13242.
PMID: 39494519
G-quadruplexes (G4s) formed within RNA are emerging as promising targets for therapeutic intervention in cancer, neurodegenerative disorders and infectious diseases. Sequences containing a succession of short GG blocks, or uneven...
6.
Figueiredo J, Carreira-Barral I, Lourenco P, Miranda A, Lopes-Nunes J, Quesada R, et al.
ChemMedChem
. 2024 Nov;
20(4):e202400591.
PMID: 39487698
Novel 1,10-phenanthroline-2,9-bistriazoles derivatives have been synthesized by copper-catalyzed azide/alkyne cycloaddition reactions and assessed for their ability to bind and stabilize G-quadruplex (G4) structures. Ten novel compounds were evaluated using Förster...
7.
Dobrovolna M, Mergny J, Brazda V
Biochimie
. 2024 Oct;
229():49-57.
PMID: 39389449
Recent advancements have finally delivered a complete human genome assembly, including the elusive Y chromosome. This accomplishment closes a significant knowledge gap. Prior efforts were hampered by challenges in sequencing...
8.
Liu B, Wang T, Qiu D, Yan X, Liu Y, Mergny J, et al.
Anal Chem
. 2024 Aug;
96(36):14590-14597.
PMID: 39183481
Hemin/G-quadruplex (hG4) complexes are frequently used as artificial peroxidase-like enzymatic systems (termed G4 DNAzymes) in many biosensing applications, in spite of a rather low efficiency, notably in terms of detection...
9.
Zhang R, Wang Y, Wang C, Sun X, Mergny J
BMC Biol
. 2024 Aug;
22(1):177.
PMID: 39183303
Background: Cis-regulatory elements (CREs) are crucial for regulating gene expression, and G-quadruplexes (G4s), as prototypal non-canonical DNA structures, may play a role in this regulation. However, the relationship between G4s...
10.
Mao X, Chen Q, Wei S, Qiu D, Zhang X, Lei J, et al.
Anal Chem
. 2024 Aug;
96(33):13371-13378.
PMID: 39116285
Biomimetic enzymes have emerged as ideal alternatives to natural enzymes, and there is considerable interest in designing biomimetic enzymes with enhanced catalytic performance to address the low activity of the...