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Anne-Renee Hartman

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Recent Articles
1.
Klein E, Madhavan S, Beer T, Bettegowda C, Liu M, Hartman A, et al.
Cancer Epidemiol Biomarkers Prev . 2023 May; 32(8):1003-1010. PMID: 37255363
Cancer is a significant burden worldwide that adversely impacts life expectancy, quality of life, health care costs, and workforce productivity. Although currently recommended screening tests for individual cancers reduce mortality,...
2.
Kurian A, Hughes E, Handorf E, Gutin A, Allen B, Hartman A, et al.
JCO Precis Oncol . 2022 Feb; 1:1-12. PMID: 35172496
Purpose: Multiple-gene, next-generation sequencing panels are increasingly used to assess hereditary cancer risks of patients with diverse personal and family cancer histories. The magnitude of breast and ovarian cancer risk...
3.
Hackshaw A, Clarke C, Hartman A
Cancer Cell . 2022 Feb; 40(2):109-113. PMID: 35120599
Cancers other than breast, colorectal, cervical, and lung do not have guideline-recommended screening. New multi-cancer early detection (MCED) tests-using a single blood sample-have been developed based on circulating cell-free DNA...
4.
Mathios D, Johansen J, Cristiano S, Medina J, Phallen J, Larsen K, et al.
Nat Commun . 2021 Aug; 12(1):5060. PMID: 34417454
Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of...
5.
Idos G, Kurian A, Ricker C, Sturgeon D, Culver J, Kingham K, et al.
JCO Precis Oncol . 2021 Jul; 3. PMID: 34322651
Purpose: Multiplex gene panel testing (MGPT) allows for the simultaneous analysis of germline cancer susceptibility genes. This study describes the diagnostic yield and patient experiences of MGPT in diverse populations....
6.
Clarke C, Hubbell E, Kurian A, Colditz G, Hartman A, Gomez S
Cancer Epidemiol Biomarkers Prev . 2020 Apr; 29(5):895-902. PMID: 32229577
Background: New technologies are being developed for early detection of multiple types of cancer simultaneously. To quantify the potential benefit, we estimated reductions in absolute cancer-related deaths that could occur...
7.
Ricker C, Koff R, Qu C, Culver J, Sturgeon D, Kingham K, et al.
Transl Behav Med . 2018 Feb; 8(1):85-94. PMID: 29385580
Research on the communication of genetic test results has focused predominately on non-Hispanic White (NHW) mutation-positive families with high-risk hereditary cancer conditions. Little is known about this process for racially...
8.
Telli M, Hellyer J, Audeh W, Jensen K, Bose S, Timms K, et al.
Breast Cancer Res Treat . 2017 Dec; 168(3):625-630. PMID: 29275435
Purpose: Defects in the homologous recombination (HR) DNA repair pathway sensitize tumors to therapeutics that target this pathway. A significant proportion of triple-negative breast cancers (TNBC) carry HR defects. The...
9.
Chaffee K, Oberg A, McWilliams R, Majithia N, Allen B, Kidd J, et al.
Genet Med . 2017 Jul; 20(1):119-127. PMID: 28726808
PurposePanel-based genetic testing has identified increasing numbers of patients with pancreatic ductal adenocarcinoma (PDAC) who carry germ-line mutations. However, small sample sizes or number of genes evaluated limit prevalence estimates...
10.
Ko J, Matharoo-Ball B, Billings S, Thomson B, Tang J, Sarin K, et al.
Cancer Epidemiol Biomarkers Prev . 2017 Apr; 26(7):1107-1113. PMID: 28377414
Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from...