Anne-Pascale Luzy
Overview
Explore the profile of Anne-Pascale Luzy including associated specialties, affiliations and a list of published articles.
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14
Citations
51
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Recent Articles
1.
Ouvry G, Clary L, Tomas L, Aurelly M, Bonnary L, Borde E, et al.
ACS Med Chem Lett
. 2019 Nov;
10(11):1561-1567.
PMID: 31749911
Minor structural modifications-sometimes single atom changes-can have a dramatic impact on the properties of compounds. This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in...
2.
Barcham R, Orsini N, Andres E, Hundt A, Luzy A
Mutat Res Genet Toxicol Environ Mutagen
. 2018 Apr;
829-830:75-86.
PMID: 29704997
We investigated the commercially available Episkin LM™ reconstructed epidermis test system as a potential 3D model for human genotoxicity assessment by cytokinesis-block micronucleus assay to mitigate limitations of the currently...
3.
Fournier J, Clary L, Chambon S, Dumais L, Harris C, Millois C, et al.
J Med Chem
. 2018 Apr;
61(9):4030-4051.
PMID: 29648825
The use of an interleukin β antibody is currently being investigated in the clinic for the treatment of acne, a dermatological disorder affecting 650M persons globally. Inhibiting the protease responsible...
4.
Ouvry G, Bihl F, Bouix-Peter C, Christin O, Defoin-Platel C, Deret S, et al.
Bioorg Med Chem Lett
. 2018 Mar;
28(8):1269-1273.
PMID: 29571573
Progress in the identification of suitable RORγ inverse agonists as clinical candidates has been hampered by the high lipophilicity that seems required for high potency on this nuclear receptor. In...
5.
Fournier J, Bouix-Peter C, Duvert D, Luzy A, Ouvry G
J Med Chem
. 2018 Mar;
61(7):3231-3236.
PMID: 29547279
Phototoxicity occurs when UV irradiation causes otherwise benign compounds to become irritant, sensitizers, or even genotoxic. This toxicity is particularly a concern after topical application and in dermatological programs where...
6.
Ouvry G, Atrux-Tallau N, Bihl F, Bondu A, Bouix-Peter C, Carlavan I, et al.
ChemMedChem
. 2018 Jan;
13(4):321-337.
PMID: 29327456
With possible implications in multiple autoimmune diseases, the retinoic acid receptor-related orphan receptor RORγ has become a sought-after target in the pharmaceutical industry. Herein are described the efforts to identify...
7.
Bouvier G, Astri S, Orsini N, Kunze G, Luzy A, Gross D
Sci Total Environ
. 2018 Jan;
625:262-263.
PMID: 29289774
No abstract available.
8.
Boiteau J, Ouvry G, Arlabosse J, Astri S, Beillard A, Bhurruth-Alcor Y, et al.
Bioorg Med Chem
. 2017 Aug;
26(4):945-956.
PMID: 28818461
Targeting the TNFα pathway is a validated approach to the treatment of psoriasis. In this pathway, TACE stands out as a druggable target and has been the focus of in-house...
9.
Ouvry G, Berton Y, Bhurruth-Alcor Y, Bonnary L, Bouix-Peter C, Bouquet K, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(8):1848-1853.
PMID: 28274635
Targeting the Tumor Necrosis Factor α signalling with antibodies has led to a revolution in the treatment of psoriasis. Locally inhibiting Tumor Necrosis Factor α Converting Enzyme (TACE or ADAM17)...
10.
Ouvry G, Bouix-Peter C, Ciesielski F, Chantalat L, Christin O, Comino C, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5802-5808.
PMID: 27815118
Targeting the IL17 pathway and more specifically the nuclear receptor RORγ is thought to be beneficial in multiple skin disorders. The Letter describes the discovery of phenoxyindazoles and thiophenoxy indazoles...