Annamalai Senthilvelan
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Explore the profile of Annamalai Senthilvelan including associated specialties, affiliations and a list of published articles.
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27
Citations
75
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Recent Articles
1.
Senthilvelan A, Shanmugasundaram M, Kore A
Curr Protoc
. 2023 Aug;
3(8):e863.
PMID: 37639626
A facile, reliable, and efficient method for the synthesis of N -modified guanosine nucleotides such as N -[benzyl-N-(propyl)carbamate]-guanosine-5'-O-monophosphate, N -[benzyl-N-(propyl)carbamate]-guanosine-5'-O-diphosphate, N -[benzyl-N-(propyl)carbamate]-guanosine-5'-O-triphosphate, and N -[benzyl-N-(propyl)carbamate]-N -methyl-guanosine-5'-O-diphosphate, starting from the corresponding...
2.
Senthilvelan A, Shanmugasundaram M, Kore A
Curr Protoc
. 2023 May;
3(5):e782.
PMID: 37219381
This unit describes a facile, reliable, and efficient method for the gram-scale chemical synthesis of unlocked nucleic acid- (UNA) nucleoside-5'-O-triphosphates such as UNA-guanosine-5'-O-triphosphate (UNA-GTP), UNA-adenosine-5'-O-triphosphate (UNA-ATP), UNA-cytidine-5'-O-triphosphate (UNA-CTP), and UNA-uridine-5'-O-triphosphate...
3.
Senthilvelan A, Vonderfecht T, Shanmugasundaram M, Potter J, Kore A
Bioorg Med Chem
. 2022 Dec;
77:117128.
PMID: 36516685
The first example of the synthesis of a new trinucleotide cap analog containing propargyl group such as mG(5')PPP(5')ApG is reported. The effect of the propargyl group in trinucleotide analog with...
4.
Senthilvelan A, Shanmugasundaram M, Kore A
Curr Protoc
. 2022 Nov;
2(11):e583.
PMID: 36342272
This article describes a simple, reliable, efficient, and improved solution-phase method for the gram-scale chemical synthesis of RNA dinucleotides such as pA pA, pA pG, and pA pU that utilizes...
5.
Shanmugasundaram M, Senthilvelan A, Kore A
Curr Protoc
. 2022 Jun;
2(6):e436.
PMID: 35723503
This article presents a simple, reliable, straight-forward, general, and efficient chemical method for the gram-scale synthesis of purine locked nucleic acid (LNA) nucleotides, such as LNA guanosine-5'-O-triphosphate (LNA-GTP) and LNA...
6.
Shanmugasundaram M, Senthilvelan A, Kore A
Chem Rec
. 2022 Apr;
22(8):e202200005.
PMID: 35420257
The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome coronavirus (SARS-CoV-2) emphasizes the importance of mRNA as a powerful tool for therapeutic applications. The chemically modified...
7.
Shanmugasundaram M, Senthilvelan A, Kore A
Nucleosides Nucleotides Nucleic Acids
. 2021 Oct;
41(1):36-44.
PMID: 34696692
A simple, reliable, straightforward, and efficient method for the gram-scale chemical synthesis of purine locked nucleic acid (LNA) nucleotides such as LNA-guanosine-5'-triphosphate (LNA-GTP) and LNA-adenosine-5'-triphosphate (LNA-ATP) starting from the corresponding...
8.
Senthilvelan A, Vonderfecht T, Shanmugasundaram M, Pal I, Potter J, Kore A
Org Lett
. 2021 May;
23(11):4133-4136.
PMID: 34008991
The synthesis of a new trinucleotide cap analogue containing a locked nucleic acid (LNA) moiety such as mG(5')ppp(5')ApG and its molecular biology applications are described. The most appealing feature is...
9.
Shanmugasundaram M, Senthilvelan A, Kore A
Curr Protoc
. 2021 Jan;
1(1):e22.
PMID: 33484497
This article describes a reliable and efficient method for synthesis of the dinucleotide cap analog m G[5']ppp[5']G containing a locked nucleic acid moiety. The required LNA intermediate for the final...
10.
Shanmugasundaram M, Senthilvelan A, Kore A
Tetrahedron Lett
. 2020 Sep;
61(44):152464.
PMID: 32981977
The 1,3-dipolar cycloaddition reaction of 3'--propargyl guanosine with various generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly...