Highly Regioselective 1,3-dipolar Cycloaddition of 3'--propargyl Guanosine with Nitrile Oxide: An Efficient Method for the Synthesis of Guanosine Containing Isoxazole Moiety

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2020 Sep 28

PMID 32981977

Citations 3

Authors

Muthian Shanmugasundaram

Annamalai Senthilvelan

Anilkumar R Kore

Affiliations

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Abstract

The 1,3-dipolar cycloaddition reaction of 3'--propargyl guanosine with various generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically important guanosine containing isoxazole moiety in good yields with high purities.

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Highly regioselective 1,3-dipolar cycloaddition of 3'--propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety.

Shanmugasundaram M, Senthilvelan A, Kore A Tetrahedron Lett. 2020; 61(44):152464.

PMID: 32981977 PMC: 7501312. DOI: 10.1016/j.tetlet.2020.152464.

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