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Anna Moshnikova

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Articles 35
Citations 928
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Recent Articles
1.
Bagchi S, Yuan R, Huang H, Zhang W, Chiu D, Kim H, et al.
Sci Immunol . 2024 Oct; 9(100):eadg6453. PMID: 39423285
Multiple cancers, including colorectal cancer (CRC), are more frequent and often more aggressive in individuals with obesity. Here, we showed that macrophages accumulated within tumors of patients with obesity and...
2.
Moshnikova A, DuPont M, Iraca M, Klumpp C, Visca H, Allababidi D, et al.
Front Pharmacol . 2024 Mar; 15:1346756. PMID: 38495104
We have developed a delivery approach that uses two pHLIP peptides that collaborate in the targeted intracellular delivery of a single payload, dimeric STINGa (dMSA). dMSA was conjugated with two...
3.
DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman D, et al.
Int J Pharm . 2024 Mar; 654:123954. PMID: 38428548
Calicheamicin is a potent, cell-cycle independent enediyne antibiotic that binds and cleaves DNA. Toxicity has led to its use in a targeted form, as an antibody-drug conjugate approved for the...
4.
Matsui T, Toda Y, Sato H, Itagaki R, Konishi K, Moshnikova A, et al.
Front Oncol . 2023 Nov; 13:1258442. PMID: 38033489
Dysregulated extracellular pH, the universal feature of tumor, works as an evolutional force to drive dissemination of tumor cells. It is well-established that tumor acidity is associated with tumor growth...
5.
DuPont M, Visca H, Moshnikova A, Engelman D, Reshetnyak Y, Andreev O
Front Bioeng Biotechnol . 2023 Jan; 10:1082290. PMID: 36686229
Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a...
6.
Moshnikova A, Golijanin B, Amin A, Doyle J, Kott O, Gershman B, et al.
Front Urol . 2022 Nov; 2. PMID: 36439552
Acidity is a useful biomarker for the targeting of metabolically active-cells in tumors. pH Low Insertion Peptides (pHLIPs) sense the pH at the surfaces of tumor cells and can facilitate...
7.
Moshnikova A, DuPont M, Visca H, Engelman D, Andreev O, Reshetnyak Y
Front Oncol . 2022 Nov; 12:1023959. PMID: 36330464
Despite significant progress in the development of novel STING agonists (STINGa), applications appear to be challenged by the low efficiency and poor selectivity of these agents. A pH Low Insertion...
8.
Visca H, DuPont M, Moshnikova A, Crawford T, Engelman D, Andreev O, et al.
Mol Imaging Biol . 2022 May; 24(6):874-885. PMID: 35604527
Purpose: Acidity can be a useful alternative biomarker for the targeting of metabolically active cells in certain diseased tissues, as in acute inflammation or aggressive tumors. We investigated the targeting...
9.
Zhang X, Rotllan N, Canfran-Duque A, Sun J, Toczek J, Moshnikova A, et al.
Circ Res . 2022 May; 131(1):77-90. PMID: 35534923
Background: miRNA therapeutics have gained attention during the past decade. These oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be used to correct the imbalance of...
10.
Hulikova A, Park K, Loonat A, Gunadasa-Rohling M, Curtis M, Chung Y, et al.
Basic Res Cardiol . 2022 Mar; 117(1):17. PMID: 35357563
Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may become relevant in response to changes...