Dhammika Weerakkody
Overview
Explore the profile of Dhammika Weerakkody including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
342
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Crawford T, Moshnikova A, Roles S, Weerakkody D, DuPont M, Carter L, et al.
Sci Rep
. 2020 Oct;
10(1):18356.
PMID: 33110131
Fluorescence imaging has seen enduring use in blood flow visualization and is now finding a new range of applications in image-guided surgery. In this paper, we report a translational study...
2.
Slaybaugh G, Weerakkody D, Engelman D, Andreev O, Reshetnyak Y
Proc Natl Acad Sci U S A
. 2020 May;
117(22):12095-12100.
PMID: 32409607
To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near...
3.
Karabadzhak A, Weerakkody D, Deacon J, Andreev O, Reshetnyak Y, Engelman D
Biophys J
. 2018 May;
114(9):2107-2115.
PMID: 29742404
The physical properties of lipid bilayers, such as curvature and fluidity, can affect the interactions of polypeptides with membranes, influencing biological events. Additionally, given the growing interest in peptide-based therapeutics,...
4.
Weerakkody D, Andreev O, Reshetnyak Y
Biochem Biophys Rep
. 2017 Jul;
8:290-295.
PMID: 28664189
The investigation of pH-dependent membrane-associated folding has both fundamental interest and practical applications for targeting of acidic tumors and specific delivery of therapeutic molecules across membrane of cancer cells. We...
5.
Narayanan T, Weerakkody D, Karabadzhak A, Anderson M, Andreev O, Reshetnyak Y
J Phys Chem B
. 2016 Oct;
120(44):11484-11491.
PMID: 27726396
pH (Low) Insertion Peptides (pHLIP peptides) find application in studies of membrane-associated folding because spontaneous insertion of these peptides is conveniently triggered by varying pH. Here, we employed small-angle X-ray...
6.
Weerakkody D, Moshnikova A, El-Sayed N, Adochite R, Slaybaugh G, Golijanin J, et al.
Sci Rep
. 2016 Aug;
6:31322.
PMID: 27515582
A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent...
7.
Weerakkody D, Moshnikova A, Thakur M, Moshnikova V, Daniels J, Engelman D, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(15):5834-9.
PMID: 23530249
Cancer is a complex disease with a range of genetic and biochemical markers within and among tumors, but a general tumor characteristic is extracellular acidity, which is associated with tumor...
8.
Karabadzhak A, Weerakkody D, Wijesinghe D, Thakur M, Engelman D, Andreev O, et al.
Biophys J
. 2012 Jul;
102(8):1846-55.
PMID: 22768940
The membrane-associated folding/unfolding of pH (low) insertion peptide (pHLIP) provides an opportunity to study how sequence variations influence the kinetics and pathway of peptide insertion into bilayers. Here, we present...
9.
Barrera F, Weerakkody D, Anderson M, Andreev O, Reshetnyak Y, Engelman D
J Mol Biol
. 2011 Sep;
413(2):359-71.
PMID: 21888917
We have used pHLIP® [pH (low) insertion peptide] to study the roles of carboxyl groups in transmembrane (TM) peptide insertion. pHLIP binds to the surface of a lipid bilayer as...
10.
Andreev O, Karabadzhak A, Weerakkody D, Andreev G, Engelman D, Reshetnyak Y
Proc Natl Acad Sci U S A
. 2010 Feb;
107(9):4081-6.
PMID: 20160113
What are the molecular events that occur when a peptide inserts across a membrane or exits from it? Using the pH-triggered insertion of the pH low insertion peptide to enable...