Anna Koferle
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Explore the profile of Anna Koferle including associated specialties, affiliations and a list of published articles.
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12
Citations
265
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Recent Articles
1.
Hoffmann T, Hormann A, Corcokovic M, Zmajkovic J, Hinterndorfer M, Salkanovic J, et al.
Elife
. 2023 Aug;
12.
PMID: 37552050
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on...
2.
Wilding B, Scharn D, Bose D, Baum A, Santoro V, Chetta P, et al.
Nat Cancer
. 2022 Jul;
3(7):821-836.
PMID: 35883003
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster...
3.
Koferle A, Schlattl A, Hormann A, Thatikonda V, Popa A, Spreitzer F, et al.
Cell Rep
. 2022 Apr;
39(2):110636.
PMID: 35417719
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for...
4.
Breunig C, Koferle A, Neuner A, Wiesbeck M, Baumann V, Stricker S
Physiol Rev
. 2020 Jun;
101(1):177-211.
PMID: 32525760
Given the large amount of genome-wide data that have been collected during the last decades, a good understanding of how and why cells change during development, homeostasis, and disease might...
5.
Baumann V, Wiesbeck M, Breunig C, Braun J, Koferle A, Ninkovic J, et al.
Nat Commun
. 2019 May;
10(1):2119.
PMID: 31073172
Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular transcriptional control. However, it is unclear which molecular processes...
6.
Saint M, Bertaux F, Tang W, Sun X, Game L, Koferle A, et al.
Nat Microbiol
. 2019 Feb;
4(3):480-491.
PMID: 30718845
Phenotypic cell-to-cell variability is a fundamental determinant of microbial fitness that contributes to stress adaptation and drug resistance. Gene expression heterogeneity underpins this variability but is challenging to study genome-wide....
7.
Breunig C, Durovic T, Neuner A, Baumann V, Wiesbeck M, Koferle A, et al.
PLoS One
. 2018 Apr;
13(4):e0196015.
PMID: 29702666
Novel applications based on the bacterial CRISPR system make genetic, genomic, transcriptional and epigenomic engineering widely accessible for the first time. A significant advantage of CRISPR over previous methods is...
8.
Koferle A, Stricker S
J Vis Exp
. 2017 Dec;
(130).
PMID: 29286403
The popularity of the CRISPR/Cas9 system for both genome and epigenome engineering stems from its simplicity and adaptability. An effector (the Cas9 nuclease or a nuclease-dead dCas9 fusion protein) is...
9.
Stricker S, Koferle A, Beck S
Nat Rev Genet
. 2016 Nov;
18(1):51-66.
PMID: 27867193
Myriads of epigenomic features have been comprehensively profiled in health and disease across cell types, tissues and individuals. Although current epigenomic approaches can infer function for chromatin marks through correlation,...
10.
Koferle A, Worf K, Breunig C, Baumann V, Herrero J, Wiesbeck M, et al.
BMC Genomics
. 2016 Nov;
17(1):917.
PMID: 27842490
Background: The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The desire to deploy CRISPR-based methods in...