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Anna Bonomini

Explore the profile of Anna Bonomini including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 10
Citations 9
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Arianna Loregian
Chiara Bertagnin
Peng Zhan
Xinyong Liu
Jiwei Zhang
Ruifang Jia
Bing Huang
Xiuli Ma
Serena Massari
Oriana Tabarrini
Published In
Eur J Med Chem
J Med Chem
J Enzyme Inhib Med Chem
Antiviral Res
Org Biomol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches
Bonomini A, Mercorelli B, Loregian A
Cell Mol Life Sci . 2025 Feb; 82(1):75. PMID: 39945883
Influenza viruses still represent a great concern for Public Health by causing yearly seasonal epidemics and occasionally worldwide pandemics. Moreover, spillover events at the animal-human interface are becoming more frequent...
2.
Elaborate Structural Modifications Yielding Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Potent Neuraminidase Inhibitors with Significantly Improved Broad-Spectrum Antiresistance Profiles
Zhang J, Jia R, Jia H, Li P, Jiang Y, Bonomini A, et al.
J Med Chem . 2024 Dec; 67(24):22191-22217. PMID: 39644238
Inspired by our previous finding that targeting the 150-cavity with a multisite-binding strategy emerged as an effective approach to obtain more potent and selective neuraminidase (NA) inhibitors against influenza virus,...
3.
Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization
Bonomini A, Felicetti T, Pacetti M, Bertagnin C, Coletti A, Giammarino F, et al.
Eur J Med Chem . 2024 Aug; 277:116737. PMID: 39153334
Influenza viruses (IV) are single-stranded RNA viruses with a negative-sense genome and have the potential to cause pandemics. While vaccines exist for influenza, their protection is only partial. Additionally, there...
4.
Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo
Bonomini A, Zhang J, Ju H, Zago A, Pacetti M, Tabarrini O, et al.
Antiviral Res . 2024 Aug; 230:105980. PMID: 39117284
In search of novel therapeutic options to treat influenza virus (IV) infections, we previously identified a series of inhibitors that act by disrupting the interactions between the PA and PB1...
5.
Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA-PB1 Subunits Interaction
Giacchello I, Cianciusi A, Bertagnin C, Bonomini A, Francesconi V, Mori M, et al.
Pharmaceutics . 2024 Jul; 16(7). PMID: 39065650
The limited range of available flu treatments due to virus mutations and drug resistance have prompted the search for new therapies. RNA-dependent RNA polymerase (RdRp) is a heterotrimeric complex of...
6.
Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-]pyrimidines
Pacetti M, Pismataro M, Felicetti T, Giammarino F, Bonomini A, Tiecco M, et al.
Org Biomol Chem . 2024 Jan; 22(4):767-783. PMID: 38167738
Among the eight different triazolopyrimidine isomers existing in nature, 1,2,4-triazolo[1,5-]pyrimidine (TZP) is one of the most studied and used isomers in medicinal chemistry. For some years, our group has been...
7.
A novel -heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation
Zhang J, Liu C, Jia R, Zhang X, Zhang J, Bertagnin C, et al.
J Enzyme Inhib Med Chem . 2023 Nov; 38(1):2277135. PMID: 37955306
Our previous studies have shown that the introduction of structurally diverse benzyl side chains at the C5-NH position of oseltamivir to occupy 150-cavity contributes to the binding affinity with neuraminidase...
8.
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties
Jia R, Zhang J, Shi F, Bonomini A, Lucca C, Bertagnin C, et al.
Eur J Med Chem . 2023 Mar; 252:115275. PMID: 36931117
To yield potent neuraminidase inhibitors with improved drug resistance and favorable drug-like properties, two series of novel oseltamivir derivatives targeting the 150-cavity of neuraminidase were designed, synthesized, and biologically evaluated....
9.
Discovery of Novel Boron-Containing -Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant
Jia R, Zhang J, Zhang J, Bertagnin C, Bonomini A, Guizzo L, et al.
Molecules . 2022 Oct; 27(19). PMID: 36234966
To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing -substituted oseltamivir derivatives were designed and synthesized to target the 150-cavity of neuraminidase (NA). In...
10.
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors Targeting 150-Cavity
Ju H, Hou L, Zhao F, Zhang Y, Jia R, Guizzo L, et al.
J Med Chem . 2022 Aug; 65(17):11550-11573. PMID: 35939763
With our continuous endeavors in seeking neuraminidase (NA) inhibitors, we reported herein three series of novel oseltamivir amino derivatives with the goal of exploring the druggable chemical space inside the...