Ann Koay
Overview
Explore the profile of Ann Koay including associated specialties, affiliations and a list of published articles.
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14
Citations
436
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0
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Recent Articles
1.
Goh M, Fu L, Seetoh W, Koay A, Hua H, Tan S, et al.
Chemosphere
. 2023 Nov;
349:140740.
PMID: 38006918
Phthalates are extensively used as plasticizers in diverse consumer care products but have been reported to cause adverse health effects in humans. A commonly used phthalate, di-2-ethylhexylphthalate (DEHP) causes developmental...
2.
Soh R, Fu L, Guo W, Seetoh W, Koay A
Food Funct
. 2023 Nov;
14(24):10700-10708.
PMID: 37986606
The human bitter taste 2 receptor member 16 (TAS2R16) is one of 25 class A G-protein-coupled receptors (GPCRs) and responds to a variety of molecules responsible for the bitter taste...
3.
Nicholas Chua B, Guo W, Teng Wong H, Ow D, Leng Ho P, Koh W, et al.
Food Chem
. 2023 Jun;
426:136580.
PMID: 37331142
With growing concerns over the health impact of sugar, brazzein offers a viable alternative due to its sweetness, thermostability, and low risk profile. Here, we demonstrated the ability of protein...
4.
Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong Y, et al.
ACS Infect Dis
. 2019 Jan;
5(3):326-335.
PMID: 30682246
Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(NG37) methyltransferase (TrmD), which...
5.
Ngo A, Koay A, Pecquet C, Diaconu C, Jenkins D, Shiau A, et al.
Methods Mol Biol
. 2018 May;
1787:53-66.
PMID: 29736709
An inhibitor for the thrombopoietin receptor (TpoR) would be more specific for the treatment of myeloproliferative neoplasms (MPNs) due to constitutively active mutant TpoR compared to the current treatment approach...
6.
Gooley P, Koay A, Mobbs J
Methods Mol Biol
. 2018 Feb;
1732:87-98.
PMID: 29480470
Understanding the kinetics of proteins interacting with their ligands is important for characterizing molecular mechanism. However, it can be difficult to determine the extent and nature of these interactions for...
7.
Chachoua I, Pecquet C, El-Khoury M, Nivarthi H, Albu R, Marty C, et al.
Blood
. 2015 Dec;
127(10):1325-35.
PMID: 26668133
Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9 inducing a -1/+2 frameshift are associated with a significant fraction of myeloproliferative neoplasms (MPNs). The mechanisms...
8.
Mobbs J, Koay A, Di Paolo A, Bieri M, Petrie E, Gorman M, et al.
Biochem J
. 2015 Mar;
468(2):245-57.
PMID: 25774984
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is important in regulating energy metabolism in all eukaryotes. The β-subunit exists in two isoforms (β1 and β2) and contains a...
9.
Emanuelle S, Hossain M, Moller I, Pedersen H, van de Meene A, Doblin M, et al.
Plant J
. 2015 Mar;
82(2):183-92.
PMID: 25736509
SNF1-related protein kinase 1 (SnRK1) is the plant orthologue of the evolutionarily-conserved SNF1/AMPK/SnRK1 protein kinase family that contributes to cellular energy homeostasis. Functional as heterotrimers, family members comprise a catalytic...
10.
Bieri M, Mobbs J, Koay A, Louey G, Mok Y, Hatters D, et al.
Biophys J
. 2012 Feb;
102(2):305-14.
PMID: 22339867
AMP-activated protein kinase interacts with oligosaccharides and glycogen through the carbohydrate-binding module (CBM) containing the β-subunit, for which there are two isoforms (β(1) and β(2)). Muscle-specific β(2)-CBM, either as an...