Anja Hagting
Overview
Explore the profile of Anja Hagting including associated specialties, affiliations and a list of published articles.
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6
Citations
617
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Recent Articles
1.
Abdelbaki A, Ascanelli C, Okoye C, Akman H, Janson G, Min M, et al.
Life Sci Alliance
. 2022 Nov;
6(2).
PMID: 36450448
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket....
2.
Di Fiore B, Davey N, Hagting A, Izawa D, Mansfeld J, Gibson T, et al.
Dev Cell
. 2015 Feb;
32(3):358-372.
PMID: 25669885
The anaphase-promoting complex or cyclosome (APC/C) is the ubiquitin ligase that regulates mitosis by targeting specific proteins for degradation at specific times under the control of the spindle assembly checkpoint...
3.
Grallert A, Boke E, Hagting A, Hodgson B, Connolly Y, Griffiths J, et al.
Nature
. 2014 Dec;
517(7532):94-98.
PMID: 25487150
The widespread reorganization of cellular architecture in mitosis is achieved through extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase network and repression of counteracting phosphatases. Phosphatase...
4.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al.
EMBO J
. 2003 Dec;
22(24):6598-609.
PMID: 14657031
The anaphase-promoting complex (APC) or cyclosome is a ubiquitin ligase that initiates anaphase and mitotic exit. APC activation is thought to depend on APC phosphorylation and Cdc20 binding. We have...
5.
Hagting A, Den Elzen N, Vodermaier H, Waizenegger I, Peters J, Pines J
J Cell Biol
. 2002 Jun;
157(7):1125-37.
PMID: 12070128
Progress through mitosis is controlled by the sequential destruction of key regulators including the mitotic cyclins and securin, an inhibitor of anaphase whose destruction is required for sister chromatid separation....
6.
Jackman M, Kubota Y, Den Elzen N, Hagting A, Pines J
Mol Biol Cell
. 2002 Mar;
13(3):1030-45.
PMID: 11907280
Cyclins A and E and their partner cyclin-dependent kinases (Cdks) are key regulators of DNA synthesis and of mitosis. Immunofluorescence studies have shown that both cyclins are nuclear and that...