Anita Bosak
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Explore the profile of Anita Bosak including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Structural isomers of saligenin-based β2-agonists: synthesis and insight into the reaction mechanism
Knezevic A, Novak J, Bosak A, Vinkovic M
Org Biomol Chem
. 2020 Nov;
18(47):9675-9688.
PMID: 33220672
Salmeterol and albuterol are well-known β2-adenoreceptor agonists widely used in the treatment of inflammatory respiratory diseases, such as bronchial asthma and chronic obstructive pulmonary disease. Here we report the preparation...
12.
Bosak A, Bavec A, Konte T, Sinko G, Kovarik Z, Golicnik M
Molecules
. 2020 Jan;
25(1).
PMID: 31947900
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant...
13.
Bosak A, Opsenica D, Sinko G, Zlatar M, Kovarik Z
Chem Biol Interact
. 2019 May;
308:101-109.
PMID: 31100281
Eight derivatives of 4-aminoquinolines differing in the substituents attached to the C(4)-amino group and C(7) were synthesised and tested as inhibitors of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Both enzymes...
14.
Bosak A, Ramic A, Smidlehner T, Hrenar T, Primozic I, Kovarik Z
PLoS One
. 2018 Oct;
13(10):e0205193.
PMID: 30289893
This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound was...
15.
Katalinic M, Sinko G, Macek Hrvat N, Zorbaz T, Bosak A, Kovarik Z
Toxicology
. 2018 May;
406-407:104-113.
PMID: 29772260
The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Understanding their interactions within...
16.
Bosak A, Knezevic A, Gazic Smilovic I, Sinko G, Kovarik Z
J Enzyme Inhib Med Chem
. 2017 Jun;
32(1):789-797.
PMID: 28573890
We investigated the influence of bronchodilating β2-agonists on the activity of human acetylcholinesterase (AChE) and usual, atypical and fluoride-resistant butyrylcholinesterase (BChE). We determined the inhibition potency of racemate and enantiomers...
17.
Bosak A, Gazic Smilovic I, Stimac A, Vinkovic V, Sinko G, Kovarik Z
Arch Biochem Biophys
. 2012 Dec;
529(2):140-5.
PMID: 23219600
In this study we related metacarb (N-(2-(3,5-bis(dimethylcarbamoyloxy)phenyl)-2-hydroxyethyl)propan-2-aminium chloride) and isocarb (N-(2-(3,4-bis(dimethylcarbamoyloxy)phenyl)-2-hydroxyethyl)propan-2-aminium chloride) inhibition selectivity, as well as stereoselectivity of mouse acetylcholinesterase (AChE; 3.1.1.7) and butyrylcholinesterase (BChE; 3.1.1.8) to the active...
18.
Bosak A, Gazic Smilovic I, Sinko G, Vinkovic V, Kovarik Z
J Med Chem
. 2012 Jul;
55(15):6716-23.
PMID: 22817559
Metaproterenol and isoproterenol are bronchodilators that provide a structural basis for many other bronchodilators currently in use. One of these structurally related bronchodilators is terbutaline; it is administered as a...
19.
Bosak A, Katalinic M, Kovarik Z
Arh Hig Rada Toksikol
. 2011 Jun;
62(2):175-90.
PMID: 21705306
Enzymes acetylcholinesterase (AChE; E.C. 3.1.1.7) and butyrylcholinesterase (BChE; E.C. 3.1.1.8) have intensively been investigated in biomedicine and toxicology due to important role in organisms. Even if structurally homologous, they differ...
20.
Bosak A, Barlovic-Tusek B, Reiner E
J Enzyme Inhib Med Chem
. 2008 Jul;
23(4):521-5.
PMID: 18665999
The aim of this study was to differentiate the EDTA-sensitive from the EDTA-insensitive human serum esterases by evaluating their catalytic constants, K(M) and V(m), for the hydrolysis of phenylacetate (PA)....