Angela Pacitto
Overview
Explore the profile of Angela Pacitto including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
238
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0
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Recent Articles
1.
Trapero A, Pacitto A, Chan D, Abell C, Blundell T, Ascher D, et al.
Bioorg Med Chem Lett
. 2019 Nov;
30(2):126792.
PMID: 31757668
Inosine-5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme involved in nucleotide biosynthesis. Because of its critical role in purine biosynthesis, IMPDH is a drug design target for immunosuppressive, anticancer, antiviral and...
2.
Singh V, Pacitto A, Donini S, Ferraris D, Boros S, Illyes E, et al.
Eur J Med Chem
. 2019 May;
174:309-329.
PMID: 31055147
Tuberculosis (TB) is a major infectious disease associated increasingly with drug resistance. Thus, new anti-tubercular agents with novel mechanisms of action are urgently required for the treatment of drug-resistant TB....
3.
Trapero A, Pacitto A, Singh V, Sabbah M, Coyne A, Mizrahi V, et al.
J Med Chem
. 2018 Mar;
61(7):2806-2822.
PMID: 29547284
Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5'-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de...
4.
Singh V, Donini S, Pacitto A, Sala C, Hartkoorn R, Dhar N, et al.
ACS Infect Dis
. 2016 Oct;
3(1):5-17.
PMID: 27726334
VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in...
5.
Park Y, Pacitto A, Bayliss T, Cleghorn L, Wang Z, Hartman T, et al.
ACS Infect Dis
. 2016 Oct;
3(1):18-33.
PMID: 27704782
A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of >100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This noncytotoxic compound did not directly inhibit cell wall biogenesis...
6.
Pacitto A, Ascher D, Wong L, Blaszczyk B, Nookala R, Zhang N, et al.
Open Biol
. 2015 Dec;
5(12):150174.
PMID: 26631379
The folliculin/Fnip complex has been demonstrated to play a crucial role in the mechanisms underlying Birt-Hogg-Dubé (BHD) syndrome, a rare inherited cancer syndrome. Lst4 has been previously proposed to be...
7.
Nookala R, Langemeyer L, Pacitto A, Ochoa-Montano B, Donaldson J, Blaszczyk B, et al.
Open Biol
. 2012 Sep;
2(8):120071.
PMID: 22977732
Mutations in the renal tumour suppressor protein, folliculin, lead to proliferative skin lesions, lung complications and renal cell carcinoma. Folliculin has been reported to interact with AMP-activated kinase, a key...