Angela M Siesky
Overview
Explore the profile of Angela M Siesky including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
242
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Recent Articles
1.
Briere D, Ruan X, Cheng C, Siesky A, Fitch T, Dominguez C, et al.
PLoS One
. 2015 Aug;
10(8):e0136873.
PMID: 26312995
Activation of TGR5 via bile acids or bile acid analogs leads to the release of glucagon-like peptide-1 (GLP-1) from intestine, increases energy expenditure in brown adipose tissue, and increases gallbladder...
2.
Durham T, Toth J, Klimkowski V, Cao J, Siesky A, Alexander-Chacko J, et al.
J Biol Chem
. 2015 Jun;
290(33):20044-59.
PMID: 26085101
Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. Recently, a peptide inhibitor of IDE has been shown to affect levels of insulin, amylin,...
3.
Scheja L, Heese B, Zitzer H, Michael M, Siesky A, Pospisil H, et al.
Exp Diabetes Res
. 2008 Jun;
2008:230837.
PMID: 18584041
Acute-phase serum amyloid A (A-SAA) was shown recently to correlate with obesity and insulin resistance in humans. However, the mechanisms linking obesity-associated inflammation and elevated plasma A-SAA to insulin resistance...
4.
Sloop K, Showalter A, Cox A, Cao J, Siesky A, Zhang H, et al.
J Biol Chem
. 2007 May;
282(26):19113-21.
PMID: 17478431
D-Glucose-6-phosphatase is a key regulator of endogenous glucose production, and its inhibition may improve glucose control in type 2 diabetes. Herein, 2'-O-(2-methoxy)ethyl-modified phosphorothioate antisense oligonucleotides (ASOs) specific to the glucose...
5.
Benson M, Kluve-Beckerman B, Zeldenrust S, Siesky A, Bodenmiller D, Showalter A, et al.
Muscle Nerve
. 2006 Jan;
33(5):609-18.
PMID: 16421881
Transthyretin (TTR) amyloidosis, the most common form of hereditary systemic amyloidosis, is characterized clinically by adult-onset axonal neuropathy and restrictive cardiomyopathy. More than 85 mutations in transthyretin have been found...
6.
Sloop K, Cao J, Siesky A, Zhang H, Bodenmiller D, Cox A, et al.
J Clin Invest
. 2004 Jun;
113(11):1571-81.
PMID: 15173883
Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition; however, effective therapies to block glucagon signaling...
7.
Siesky A, Kamendulis L, Klaunig J
Toxicol Sci
. 2002 Nov;
70(2):252-60.
PMID: 12441370
Chronic inhalation of 2-butoxyethanol resulted in an increase in liver hemangiosarcomas and hepatic carcinomas in male mouse liver. No increase in liver neoplasia was observed in similarly exposed male and...