Andy Hoyle
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Explore the profile of Andy Hoyle including associated specialties, affiliations and a list of published articles.
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7
Citations
68
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Recent Articles
1.
Optimising efficacy of antibiotics against systemic infection by varying dosage quantities and times
Hoyle A, Cairns D, Paterson I, McMillan S, Ochoa G, Desbois A
PLoS Comput Biol
. 2020 Aug;
16(8):e1008037.
PMID: 32745111
Mass production and use of antibiotics has led to the rise of resistant bacteria, a problem possibly exacerbated by inappropriate and non-optimal application. Antibiotic treatment often follows fixed-dose regimens, with...
2.
Kleczkowski A, Hoyle A, McMenemy P
Philos Trans R Soc Lond B Biol Sci
. 2019 May;
374(1775):20180255.
PMID: 31056049
One hundred years after the 1918 influenza outbreak, are we ready for the next pandemic? This paper addresses the need to identify and develop collaborative, interdisciplinary and cross-sectoral approaches to...
3.
Paterson I, Hoyle A, Ochoa G, Baker-Austin C, Taylor N
Sci Rep
. 2016 Nov;
6:37853.
PMID: 27892497
The increase in antibiotic resistant bacteria poses a threat to the continued use of antibiotics to treat bacterial infections. The overuse and misuse of antibiotics has been identified as a...
4.
Garbutt J, Little T, Hoyle A
Proc Biol Sci
. 2015 Dec;
282(1820):20152173.
PMID: 26631563
Maternal effects, where the conditions experienced by mothers affect the phenotype of their offspring, are widespread in nature and have the potential to influence population dynamics. However, they are very...
5.
Best A, Hoyle A
Interface Focus
. 2014 Feb;
3(6):20130024.
PMID: 24516712
A vast theoretical literature has explored the evolutionary dynamics of parasite virulence. The classic result from this modelling work is that, assuming a saturating transmission-virulence trade-off, there is a single...
6.
Best A, Hoyle A
Ecol Evol
. 2013 Aug;
3(7):2223-32.
PMID: 23919164
A key feature of the vertebrate adaptive immune system is acquired immune memory, whereby hosts launch a faster and heightened response when challenged by previously encountered pathogens, preventing full infection....
7.
Hoyle A, Bowers R, White A
Bull Math Biol
. 2010 Jul;
73(5):1154-69.
PMID: 20640525
Many studies of the evolution of life-history traits assume that the underlying population dynamical attractor is stable point equilibrium. However, evolutionary outcomes can change significantly in different circumstances. We present...