Andriy Mokhir
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Explore the profile of Andriy Mokhir including associated specialties, affiliations and a list of published articles.
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89
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734
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Recent Articles
1.
Arkhypov A, Klemt I, Bila G, Attia D, Chernii S, Bilyy R, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(5):e202417509.
PMID: 39496073
The number and stability of lysosomes (LYs) are different in cancer and healthy cells that makes them a possible target for cancer specific therapy. However, no LY-targeting drug is clinically...
2.
Chernii S, Selin R, Bila G, Bilyy R, Korber M, Mokhir A
Chemistry
. 2024 Jun;
30(48):e202401107.
PMID: 38923064
Red fluorescent dyes are usually charged, lipophilic molecules with relatively high molecular weight, which tend to localize in specific intracellular locations, e. g., a cyanine dye Cy5 is biased towards...
3.
Klemt I, Reshetnikov V, Dutta S, Bila G, Bilyy R, Cuartero I, et al.
RSC Med Chem
. 2024 Apr;
15(4):1189-1197.
PMID: 38665843
Many known chemotherapeutic anticancer agents exhibit neutropenia as a dose-limiting side effect. In this paper we suggest a prodrug concept solving this problem for camptothecin (HO-cpt). The prodrug is programmed...
4.
Schuster F, Grau B, Xu H, Mokhir A, Tsogoeva S
Bioorg Med Chem
. 2024 Mar;
103:117650.
PMID: 38492540
Reactions for drug synthesis under cell-like conditions or even inside living cells can potentially be used e.g., to minimize toxic side effects, to maximize bioactive compound efficacy and/or to address...
5.
Beierlein F, Horn A, Sticht H, Mokhir A, Imhof P
Biomolecules
. 2024 Feb;
14(2).
PMID: 38397391
Pro-drugs, which ideally release their active compound only at the site of action, i.e., in a cancer cell, are a promising approach towards an increased specificity and hence reduced side...
6.
Klemt I, Varzatskii O, Selin R, Vakarov S, Kovalska V, Bila G, et al.
J Am Chem Soc
. 2023 Sep;
145(40):22252-22264.
PMID: 37773090
The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic reticulum (ER) stress. Therefore, cancer cells are sensitive to drugs capable of further enhancing ER stress. Examples...
7.
Ruhle J, Klemt I, Mokhir A
Molecules
. 2023 May;
28(10).
PMID: 37241945
RNA interference (RNAi) using small interfering RNAs (siRNAs) is a powerful tool to target any protein of interest and is becoming more suitable for in vivo applications due to recent...
8.
Kockenberger J, Klemt I, Sauer C, Arkhypov A, Reshetnikov V, Mokhir A, et al.
Chemistry
. 2023 May;
29(45):e202301340.
PMID: 37171462
Despite their long history and their synthetic potential underlined by various recent advances, radical thiol-yne coupling reactions have so far only rarely been exploited for the functionalization of biomolecules, and...
9.
Morozov B, Oshchepkov A, Klemt I, Agafontsev A, Krishna S, Hampel F, et al.
JACS Au
. 2023 Apr;
3(3):964-977.
PMID: 37006770
Supramolecular recognition of nucleotides would enable manipulating crucial biochemical pathways like transcription and translation directly and with high precision. Therefore, it offers great promise in medicinal applications, not least in...
10.
Aristova D, Selin R, Heil H, Kosach V, Slominsky Y, Yarmoluk S, et al.
ACS Omega
. 2023 Jan;
7(51):47734-47746.
PMID: 36591208
We propose symmetrical cationic trimethine cyanine dyes with β-substituents in the polymethine chain based on modified benzothiazole and benzoxazole heterocycles as probes for the detection and visualization of live and...