Andrey N Pravdivtsev
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Explore the profile of Andrey N Pravdivtsev including associated specialties, affiliations and a list of published articles.
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56
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746
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Recent Articles
1.
Assaf C, Gui X, Salnikov O, Brahms A, Chukanov N, Skovpin I, et al.
Commun Chem
. 2024 Dec;
7(1):286.
PMID: 39627452
The signal amplification by reversible exchange process (SABRE) enhances NMR signals by unlocking hidden polarization in parahydrogen through interactions with to-be-hyperpolarized substrate molecules when both are transiently bound to an...
2.
Mohiuddin O, de Maissin H, Pravdivtsev A, Brahms A, Herzog M, Schroder L, et al.
Commun Chem
. 2024 Oct;
7(1):240.
PMID: 39443619
Hyperpolarized C MRI visualizes real-time metabolic processes in vivo. In this study, we achieved high C polarization in situ in the bore of an MRI system for precursor molecules of...
3.
Trofimov I, Salnikov O, Pravdivtsev A, de Maissin H, Yi A, Chekmenev E, et al.
Commun Chem
. 2024 Oct;
7(1):235.
PMID: 39414912
Radio Amplification by Stimulated Emission of Radiation (RASER) is a phenomenon observed during nuclear magnetic resonance (NMR) experiments with strongly negatively polarized systems. This phenomenon may be utilized for the...
4.
Peters J, Assaf C, Mohamad F, Beitz E, Tiwari S, Aden K, et al.
Anal Chem
. 2024 Oct;
96(43):17135-17144.
PMID: 39405516
Metabolic changes in an organism often occur much earlier than macroscopic manifestations of disease, such as invasive tumors. Therefore, noninvasive tools to monitor metabolism are fundamental as they provide insights...
5.
Them K, Kuhn J, Pravdivtsev A, Hovener J
Commun Chem
. 2024 Aug;
7(1):172.
PMID: 39112677
Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic resonance. A universal tool to hyperpolarize small molecules in solution, however, has not yet emerged. Transferring hyperpolarized, labile...
6.
Salnikov O, Assaf C, Yi A, Duckett S, Chekmenev E, Hovener J, et al.
Anal Chem
. 2024 Jul;
96(29):11790-11799.
PMID: 38976810
Large signal enhancements can be obtained for NMR analytes using the process of nuclear spin hyperpolarization. Organometallic complexes that bind parahydrogen can themselves become hyperpolarized. Moreover, if parahydrogen and a...
7.
Kempf N, Korber R, Plaumann M, Pravdivtsev A, Engelmann J, Boldt J, et al.
Sci Rep
. 2024 Feb;
14(1):4468.
PMID: 38396023
Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging. Parahydrogen-based signal amplification by reversible exchange (SABRE) was employed to hyperpolarize [1-C]pyruvate...
8.
Assaf C, Gui X, Auer A, Duckett S, Hovener J, Pravdivtsev A
J Phys Chem Lett
. 2024 Jan;
15(5):1195-1203.
PMID: 38271215
Observing pyruvate metabolism has become a focal point of molecular magnetic resonance imaging. Signal amplification by reversible exchange (SABRE) has recently emerged as a versatile hyperpolarization technique. Tuning of the...
9.
Brahms A, Pravdivtsev A, Thorns L, Sonnichsen F, Hovener J, Herges R
J Org Chem
. 2023 Oct;
88(21):15018-15028.
PMID: 37824795
Metabolic changes often occur long before pathologies manifest and treatment becomes challenging. As key elements of energy metabolism, α-ketocarboxylic acids (α-KCA) are particularly interesting, e.g., as the upregulation of pyruvate...
10.
Peters J, Brahms A, Janicaud V, Anikeeva M, Peschke E, Ellermann F, et al.
Sci Adv
. 2023 Aug;
9(34):eadd3643.
PMID: 37611105
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be performed noninvasively in real time. Here,...