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Jan-Bernd Hovener

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Recent Articles
1.
Assaf C, Gui X, Salnikov O, Brahms A, Chukanov N, Skovpin I, et al.
Commun Chem . 2024 Dec; 7(1):286. PMID: 39627452
The signal amplification by reversible exchange process (SABRE) enhances NMR signals by unlocking hidden polarization in parahydrogen through interactions with to-be-hyperpolarized substrate molecules when both are transiently bound to an...
2.
Peschke E, Pravdivtseva M, Jansen O, Larsen N, Hovener J
Z Med Phys . 2024 Nov; PMID: 39616082
Vessel walls play a crucial role in many inflammatory vascular diseases. Vessel wall imaging (VWI) using mangnetic resonance imaging (MRI) is one of the few methods by which vessel walls...
3.
Mohiuddin O, de Maissin H, Pravdivtsev A, Brahms A, Herzog M, Schroder L, et al.
Commun Chem . 2024 Oct; 7(1):240. PMID: 39443619
Hyperpolarized C MRI visualizes real-time metabolic processes in vivo. In this study, we achieved high C polarization in situ in the bore of an MRI system for precursor molecules of...
4.
Trofimov I, Salnikov O, Pravdivtsev A, de Maissin H, Yi A, Chekmenev E, et al.
Commun Chem . 2024 Oct; 7(1):235. PMID: 39414912
Radio Amplification by Stimulated Emission of Radiation (RASER) is a phenomenon observed during nuclear magnetic resonance (NMR) experiments with strongly negatively polarized systems. This phenomenon may be utilized for the...
5.
Peters J, Assaf C, Mohamad F, Beitz E, Tiwari S, Aden K, et al.
Anal Chem . 2024 Oct; 96(43):17135-17144. PMID: 39405516
Metabolic changes in an organism often occur much earlier than macroscopic manifestations of disease, such as invasive tumors. Therefore, noninvasive tools to monitor metabolism are fundamental as they provide insights...
6.
Them K, Kuhn J, Pravdivtsev A, Hovener J
Commun Chem . 2024 Aug; 7(1):172. PMID: 39112677
Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic resonance. A universal tool to hyperpolarize small molecules in solution, however, has not yet emerged. Transferring hyperpolarized, labile...
7.
Salnikov O, Assaf C, Yi A, Duckett S, Chekmenev E, Hovener J, et al.
Anal Chem . 2024 Jul; 96(29):11790-11799. PMID: 38976810
Large signal enhancements can be obtained for NMR analytes using the process of nuclear spin hyperpolarization. Organometallic complexes that bind parahydrogen can themselves become hyperpolarized. Moreover, if parahydrogen and a...
8.
Cheng K, Lange-Hegermann M, Hovener J, Schreiweis B
Comput Struct Biotechnol J . 2024 Jul; 24:434-450. PMID: 38975287
A medical data integration center integrates a large volume of medical images from clinical departments, including X-rays, CT scans, and MRI scans. Ideally, all images should be indexed appropriately with...
9.
Riyaz S, Sun Y, Helmholz H, Medina T, Medina O, Wiese B, et al.
Acta Biomater . 2024 Jul; 185:41-54. PMID: 38969080
The immune system plays an important role in fracture healing, by modulating the pro-inflammatory and anti-inflammatory responses occurring instantly upon injury. An imbalance in these responses can lead to adverse...
10.
Kubelt C, Gilles L, Hellmold D, Blumenbecker T, Peschke E, Will O, et al.
Eur J Neurosci . 2024 May; 60(1):3572-3596. PMID: 38708527
Glioblastomas (GBMs) are characterized by high heterogeneity, involving diverse cell types, including those with stem-like features contributing to GBM's malignancy. Moreover, metabolic alterations promote growth and therapeutic resistance of GBM....