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Andrey E Shchekotikhin

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Articles 70
Citations 323
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Recent Articles
1.
Zhidkov M, Smirnova P, Grammatikova N, Isakova E, Shchekotikhin A, Styshova O, et al.
Mar Drugs . 2025 Feb; 23(2). PMID: 39997192
Fascaplysins form a group of marine natural products with unique cationic five-ring coplanar backbone. Native fascaplysin exhibits a broad spectrum of bioactivities, among which the cytotoxic activity has been the...
2.
Shapovalova K, Zatonsky G, Razumova E, Ipatova D, Lukianov D, Sergiev P, et al.
Antibiotics (Basel) . 2025 Jan; 13(12. PMID: 39766581
Aminoglycosides are one of the first classes of natural antibiotics which have not lost relevance due to their broad spectrum of action against Gram-positive, Gram-negative bacteria and mycobacteria. The high...
3.
Litvinova V, Tsvetkov V, Volodina Y, Dezhenkova L, Markova A, Nguyen M, et al.
Eur J Med Chem . 2024 Nov; 281:117013. PMID: 39500064
The acquisition of multidrug resistance (MDR) to chemotherapy is a major obstacle to successful cancer treatment. Aiming to improve the potency of anthraquinone-derived antitumor compounds against MDR cancer cells, we...
4.
Stepanov A, Yarovenko V, Nasyrova D, Dezhenkova L, Akchurin I, Krayushkin M, et al.
Molecules . 2024 Oct; 29(20). PMID: 39459334
Gossypol and its derivatives arouse interest due to their broad spectrum of biological activities. Despite its wide potential application, there is no reported example of gossypol derivatives bearing stable radical...
5.
Andreeva D, Tikhomirov A, Shchekotikhin A
Org Biomol Chem . 2024 Sep; 22(42):8493-8504. PMID: 39344399
Heterocyclic derivatives of anthraquinone demonstrated a high potential for the development of new antitumor compounds. In this study, we report a scheme for the synthesis of thiazole-fused anthraquinones and the...
6.
Buravchenko G, Scherbakov A, Krymov S, Salnikova D, Zatonsky G, Schols D, et al.
RSC Adv . 2024 Jul; 14(32):23257-23272. PMID: 39045402
A series of sulfonamide-derived quinoxaline 1,4-dioxides were synthesized and evaluated as inhibitors of carbonic anhydrases (CA) with antiproliferative potency. Overall, the synthesized compounds demonstrated good inhibitory activity against four CA...
7.
Islam A, Chang Y, Chen X, Weng C, Chen C, Wang C, et al.
Elife . 2024 Apr; 12. PMID: 38567911
The antibiotic heliomycin (resistomycin), which is generated from , has multiple activities, including anticancer effects. Heliomycin was first described in the 1960s, but its clinical applications have been hindered by...
8.
Volynkina I, Bychkova E, Karakchieva A, Tikhomirov A, Zatonsky G, Solovieva S, et al.
Pharmaceuticals (Basel) . 2024 Feb; 17(2). PMID: 38399402
The sustained rise of antimicrobial resistance (AMR) causes a strong need to develop new antibacterial agents. One of the methods for addressing the problem of antibiotic resistance is through the...
9.
Zhidkov M, Sidorova M, Smirnova P, Tryapkin O, Kachanov A, Kantemirov A, et al.
Mar Drugs . 2024 Feb; 22(2). PMID: 38393024
Based on the results of our own preliminary studies, the derivative of the marine alkaloid fascaplysin containing a phenyl substituent at C-9 was selected to evaluate the therapeutic potential in...
10.
Andreeva D, Vedekhina T, Gostev A, Dezhenkova L, Volodina Y, Markova A, et al.
Eur J Med Chem . 2024 Feb; 268:116222. PMID: 38387333
G-quadruplex (G4) ligands attract considerable attention as potential anticancer therapeutics. In this study we proposed an original scheme for synthesis of azole-fused anthraquinones and prepared a series of G4 ligands...