Andrey A Parkhitko
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Explore the profile of Andrey A Parkhitko including associated specialties, affiliations and a list of published articles.
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17
Citations
376
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Recent Articles
1.
Yadav S, Pan X, Li S, Martin P, Hoang N, Chen K, et al.
bioRxiv
. 2025 Jan;
PMID: 39829793
Aging is characterized by extensive metabolic dysregulation. Redox coenzyme nicotinamide adenine dinucleotide (NAD) can exist in oxidized (NAD) or reduced (NADH) states, which together form a key NADH/NAD redox pair....
2.
Gladyshev V, Anderson B, Barlit H, Barre B, Beck S, Behrouz B, et al.
PNAS Nexus
. 2024 Dec;
3(12):pgae499.
PMID: 39660064
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the...
3.
Yadav S, Graham A, Al Hammood F, Garbark C, Vasudevan D, Pandey U, et al.
Aging Cell
. 2024 Aug;
23(11):e14277.
PMID: 39137949
Neuronal cells are highly specialized cells and have a specific metabolic profile to support their function. It has been demonstrated that the metabolic profiles of different cells/tissues undergo significant reprogramming...
4.
Parkhitko A, Filine E, Tatar M
Nat Aging
. 2023 Oct;
3(10):1187-1200.
PMID: 37783817
Insight on the underlying mechanisms of aging will advance our ability to extend healthspan, treat age-related pathology and improve quality of life. Multiple genetic and pharmacological manipulations extend longevity in...
5.
Terakawa A, Hu Y, Kokaji T, Yugi K, Morita K, Ohno S, et al.
iScience
. 2022 May;
25(5):104231.
PMID: 35494245
Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic interactions. To obtain a comprehensive view of the cellular responses to insulin, we constructed a trans-omic network of insulin...
6.
Jouandin P, Marelja Z, Shih Y, Parkhitko A, Dambowsky M, Asara J, et al.
Science
. 2022 Feb;
375(6582):eabc4203.
PMID: 35175796
Adaptation to nutrient scarcity involves an orchestrated response of metabolic and signaling pathways to maintain homeostasis. We find that in the fat body of fasting , lysosomal export of cystine...
7.
Parkhitko A, Wang L, Filine E, Jouandin P, Leshchiner D, Binari R, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(40).
PMID: 34588310
Loss of metabolic homeostasis is a hallmark of aging and is characterized by dramatic metabolic reprogramming. To analyze how the fate of labeled methionine is altered during aging, we applied...
8.
Parkhitko A, Singh A, Hsieh S, Hu Y, Binari R, Lord C, et al.
PLoS Genet
. 2021 Feb;
17(2):e1009354.
PMID: 33591981
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL)...
9.
Parkhitko A, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, et al.
Elife
. 2020 Dec;
9.
PMID: 33319750
Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived . Among the metabolites that changed, levels...
10.
Lam H, Baglini C, Lope A, Parkhitko A, Liu H, Alesi N, et al.
Cancer Res
. 2020 Dec;
80(23):5424.
PMID: 33268556
No abstract available.