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Andrew W Pountain

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Citations 481
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Recent Articles
1.
Pountain A, Jiang P, Yao T, Homaee E, Guan Y, McDonald K, et al.
Nature . 2024 Jan; 626(7999):661-669. PMID: 38267581
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome. In bacteria, the relationship between the regulatory architecture of a...
2.
Miramon P, Pountain A, Lorenz M
Infect Immun . 2023 Oct; 91(11):e0027423. PMID: 37815367
The pathogenic yeast represents a global threat of the utmost clinical relevance. This emerging fungal species is remarkable in its resistance to commonly used antifungal agents and its persistence in...
3.
Pountain A, Jiang P, Yao T, Homaee E, Guan Y, Podkowik M, et al.
Res Sq . 2023 Apr; PMID: 37034646
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome. These modes interact with a changing cellular environment to yield...
4.
Avital G, Kuperwaser F, Pountain A, Lacey K, Zwack E, Podkowik M, et al.
Cell Rep . 2022 Oct; 41(2):111477. PMID: 36223751
Innate immune recognition of bacterial pathogens is a key determinant of the ensuing systemic response, and host or pathogen heterogeneity in this early interaction can impact the course of infection....
5.
Alpizar-Sosa E, Ithnin N, Wei W, Pountain A, Weidt S, Donachie A, et al.
PLoS Negl Trop Dis . 2022 Sep; 16(9):e0010779. PMID: 36170238
Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or...
6.
Pountain A, Collette J, Farrell W, Lorenz M
mBio . 2021 Dec; 12(6):e0331721. PMID: 34903044
species are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including Candida albicans, the most prevalent cause of infection, belong...
7.
Giordani F, Paape D, Vincent I, Pountain A, Fernandez-Cortes F, Rico E, et al.
PLoS Pathog . 2020 Nov; 16(11):e1008932. PMID: 33141865
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent...
8.
Pountain A, Barrett M
Wellcome Open Res . 2020 Mar; 4:176. PMID: 32133420
: Protozoan parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat infection, so understanding...
9.
Miramon P, Pountain A, van Hoof A, Lorenz M
Infect Immun . 2020 Feb; 88(5). PMID: 32094252
Nutrient acquisition is a central challenge for all organisms. For the fungal pathogen , utilization of amino acids has been shown to be critical for survival, immune evasion, and escape,...
10.
Pountain A, Weidt S, Regnault C, Bates P, Donachie A, Dickens N, et al.
PLoS Negl Trop Dis . 2019 Feb; 13(2):e0007052. PMID: 30716073
Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis,...