Andrew R Lynch
Overview
Explore the profile of Andrew R Lynch including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
29
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Recent Articles
1.
Zhou A, Tucker J, Scribano C, Lynch A, Carlsen C, Pop-Vicas S, et al.
PLoS Biol
. 2025 Feb;
23(2):e3003039.
PMID: 39938018
[This corrects the article DOI: 10.1371/journal.pbio.3002339.].
2.
Baker T, Lai S, Lynch A, Lesluyes T, Yan H, Ogilvie H, et al.
Cancer Discov
. 2024 Jun;
14(10):1810-1822.
PMID: 38943574
Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic...
3.
Lynch A, Bradford S, Zhou A, Oxendine K, Henderson L, Horner V, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(16):e2309621121.
PMID: 38588415
Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression....
4.
Zhou A, Tucker J, Scribano C, Lynch A, Carlsen C, Pop-Vicas S, et al.
PLoS Biol
. 2023 Oct;
21(10):e3002339.
PMID: 37883329
Microtubule-targeted agents are commonly used for cancer treatment, though many patients do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via mitotic arrest because they cause cell death...
5.
Lynch A, Bradford S, Zhou A, Oxendine K, Henderson L, Horner V, et al.
bioRxiv
. 2023 Jul;
PMID: 37398147
Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis-segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression....
6.
Lynch A, Arp N, Zhou A, Weaver B, Burkard M
Elife
. 2022 Apr;
11.
PMID: 35380536
Chromosomal instability (CIN)-persistent chromosome gain or loss through abnormal mitotic segregation-is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome mis-segregation rate, a measure of CIN, can inform prognosis and...