Andrew P Jackson
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Explore the profile of Andrew P Jackson including associated specialties, affiliations and a list of published articles.
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139
Citations
10354
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Recent Articles
11.
Reijns M, Parry D, Williams T, Nadeu F, Hindshaw R, Rios Szwed D, et al.
Nature
. 2022 Feb;
602(7898):623-631.
PMID: 35140396
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair. In microorganisms, transcription has been demonstrated to be mutagenic;...
12.
Tamayo-Orrego L, Gallo D, Racicot F, Bemmo A, Mohan S, Ho B, et al.
Nat Cancer
. 2022 Feb;
1(8):840-854.
PMID: 35122047
The mechanisms generating cancer-initiating mutations are not well understood. Sonic hedgehog (SHH) pathway activation is frequent in medulloblastoma (MB), with PTCH1 mutations being a common initiating event. Here we investigated...
13.
Silva Pereira S, Jackson A, Figueiredo L
Trends Parasitol
. 2021 Aug;
38(1):23-36.
PMID: 34376326
An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology...
14.
Autheman D, Crosnier C, Clare S, Goulding D, Brandt C, Harcourt K, et al.
Nature
. 2021 May;
595(7865):96-100.
PMID: 34040257
Trypanosomes are protozoan parasites that cause infectious diseases, including African trypanosomiasis (sleeping sickness) in humans and nagana in economically important livestock. An effective vaccine against trypanosomes would be an important...
15.
Midha S, Rigden D, Siozios S, Hurst G, Jackson A
ISME J
. 2021 Jan;
15(6):1680-1694.
PMID: 33452479
Bacterial endosymbiosis has been instrumental in eukaryotic evolution, and includes both mutualistic, dependent and parasitic associations. Here we characterize an intracellular bacterium inhabiting the flagellated protist Bodo saltans (Kinetoplastida). We...
16.
Reijns M, Thompson L, Carlos Acosta J, Black H, Sanchez-Luque F, Diamond A, et al.
PLoS Biol
. 2020 Dec;
18(12):e3001030.
PMID: 33320856
With the ongoing COVID-19 (Coronavirus Disease 2019) pandemic, caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), there is a need for sensitive, specific, and affordable diagnostic...
17.
Uggenti C, Lepelley A, Depp M, Badrock A, Rodero M, El-Daher M, et al.
Nat Genet
. 2020 Nov;
52(12):1364-1372.
PMID: 33230297
Inappropriate stimulation or defective negative regulation of the type I interferon response can lead to autoinflammation. In genetically uncharacterized cases of the type I interferonopathy Aicardi-Goutières syndrome, we identified biallelic...
18.
Parry D, Tamayo-Orrego L, Carroll P, Marsh J, Greene P, Murina O, et al.
Genes Dev
. 2020 Oct;
34(21-22):1520-1533.
PMID: 33060134
DNA replication is fundamental for cell proliferation in all organisms. Nonetheless, components of the replisome have been implicated in human disease, and here we report encoding the catalytic subunit of...
19.
Parry D, Martin C, Greene P, Marsh J, Blyth M, Cox H, et al.
Genet Med
. 2020 Oct;
23(2):408-414.
PMID: 33033404
Purpose: Lamins are the major component of nuclear lamina, maintaining structural integrity of the nucleus. Lamin A/C variants are well established to cause a spectrum of disorders ranging from myopathies...
20.
Zhang J, Bellani M, James R, Pokharel D, Zhang Y, Reynolds J, et al.
Nat Commun
. 2020 Aug;
11(1):3951.
PMID: 32769987
Duplication of mammalian genomes requires replisomes to overcome numerous impediments during passage through open (eu) and condensed (hetero) chromatin. Typically, studies of replication stress characterize mixed populations of challenged and...