Andrea Leitch
Overview
Explore the profile of Andrea Leitch including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
3182
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0
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Recent Articles
1.
Martin C, Sarlos K, Logan C, Thakur R, Parry D, Bizard A, et al.
Am J Hum Genet
. 2024 May;
111(5):996.
PMID: 38701747
No abstract available.
2.
Parry D, Tamayo-Orrego L, Carroll P, Marsh J, Greene P, Murina O, et al.
Genes Dev
. 2020 Oct;
34(21-22):1520-1533.
PMID: 33060134
DNA replication is fundamental for cell proliferation in all organisms. Nonetheless, components of the replisome have been implicated in human disease, and here we report encoding the catalytic subunit of...
3.
Martin C, Sarlos K, Logan C, Thakur R, Parry D, Bizard A, et al.
Am J Hum Genet
. 2018 Sep;
103(3):456.
PMID: 30193137
No abstract available.
4.
Martin C, Sarlos K, Logan C, Thakur R, Parry D, Bizard A, et al.
Am J Hum Genet
. 2018 Jul;
103(2):221-231.
PMID: 30057030
Bloom syndrome, caused by biallelic mutations in BLM, is characterized by prenatal-onset growth deficiency, short stature, an erythematous photosensitive malar rash, and increased cancer predisposition. Diagnostically, a hallmark feature is...
5.
Mackenzie K, Carroll P, Martin C, Murina O, Fluteau A, Simpson D, et al.
Nature
. 2017 Jul;
548(7668):461-465.
PMID: 28738408
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA...
6.
Martin C, Murray J, Carroll P, Leitch A, Mackenzie K, Halachev M, et al.
Genes Dev
. 2017 Jun;
31(9):953.
PMID: 28566537
No abstract available.
7.
Reynolds J, Bicknell L, Carroll P, Higgs M, Shaheen R, Murray J, et al.
Nat Genet
. 2017 Feb;
49(4):537-549.
PMID: 28191891
To ensure efficient genome duplication, cells have evolved numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify downstream neighbor of SON (DONSON)...
8.
Martin C, Murray J, Carroll P, Leitch A, Mackenzie K, Halachev M, et al.
Genes Dev
. 2016 Oct;
30(19):2158-2172.
PMID: 27737959
Compaction of chromosomes is essential for accurate segregation of the genome during mitosis. In vertebrates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic chromosome...
9.
Harley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al.
Nat Genet
. 2015 Nov;
48(1):36-43.
PMID: 26595769
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients...
10.
Murray J, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, et al.
Am J Hum Genet
. 2015 Mar;
96(3):412-24.
PMID: 25728776
Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity. Mutations in several components of the NHEJ pathway have been identified, often associated with severe combined immunodeficiency (SCID),...