Andrew P Halestrap
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Explore the profile of Andrew P Halestrap including associated specialties, affiliations and a list of published articles.
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80
Citations
7158
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Recent Articles
1.
Bernardi P, Gerle C, Halestrap A, Jonas E, Karch J, Mnatsakanyan N, et al.
Cell Death Differ
. 2023 Jul;
30(8):1869-1885.
PMID: 37460667
The mitochondrial permeability transition (mPT) describes a Ca-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It...
2.
Knapp-Wilson A, Pereira G, Buzzard E, Ford H, Richardson A, Corey R, et al.
J Cell Sci
. 2021 Jun;
134(13).
PMID: 34106255
Mitochondrial supercomplexes form around a conserved core of monomeric complex I and dimeric complex III; wherein a subunit of the former, NDUFA11, is conspicuously situated at the interface. We identified...
3.
Scott L, Vincent E, Hudson N, Neal C, Jones N, Lavelle E, et al.
JCI Insight
. 2021 Apr;
6(8).
PMID: 33884963
It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several stress...
4.
Rutter G, McCormack J, Halestrap A, Denton R
J Biol Chem
. 2020 Jul;
295(30):10506.
PMID: 32709760
No abstract available.
5.
Pereira G, Lee L, Rawlings N, Ouwendijk J, Parker J, Andrienko T, et al.
PLoS One
. 2020 Jun;
15(6):e0234653.
PMID: 32579577
We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2 release is...
6.
Andrienko T, Pasdois P, Pereira G, Ovens M, Halestrap A
J Mol Cell Cardiol
. 2017 Jul;
110:1-14.
PMID: 28689004
We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting as a key mediator of ischemia/reperfusion...
7.
Andrienko T, Pasdois P, Rossbach A, Halestrap A
PLoS One
. 2016 Dec;
11(12):e0167300.
PMID: 27907091
Mitochondrial permeability transition pore (mPTP) opening is critical for ischemia / reperfusion (I/R) injury and is associated with increased [Ca2+] and reactive oxygen species (ROS). Here we employ surface fluorescence...
8.
Nath K, Guo L, Nancolas B, Nelson D, Shestov A, Lee S, et al.
Biochim Biophys Acta
. 2016 Aug;
1866(2):151-162.
PMID: 27497601
Lonidamine (LND) was initially introduced as an antispermatogenic agent. It was later found to have anticancer activity sensitizing tumors to chemo-, radio-, and photodynamic-therapy and hyperthermia. Although the mechanism of...
9.
Richardson A, Halestrap A
Biochem J
. 2016 Feb;
473(9):1129-40.
PMID: 26920024
Inhibition of the mitochondrial permeability transition pore (MPTP) by the novel inhibitor GNX-4975 was characterized. Titration of MPTP activity in de-energized rat liver mitochondria allowed determination of the number of...
10.
Nancolas B, Guo L, Zhou R, Nath K, Nelson D, Leeper D, et al.
Biochem J
. 2016 Feb;
473(7):929-36.
PMID: 26831515
Lonidamine (LND) is an anti-tumour drug particularly effective at selectively sensitizing tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of action remains unclear. It has been reported to...