Goncalo C Pereira
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Explore the profile of Goncalo C Pereira including associated specialties, affiliations and a list of published articles.
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25
Citations
462
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Recent Articles
1.
Tavoulari S, Lacabanne D, Pereira G, Thangaratnarajah C, King M, He J, et al.
Mol Metab
. 2024 Oct;
90():102047.
PMID: 39419476
Objective: Citrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, because it consists of three domains and forms a homo-dimer. Each...
2.
de Luxan-Delgado B, Potes Y, Rubio-Gonzalez A, Solano J, Boga J, Antuna E, et al.
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201365
Despite efforts to elucidate the cellular adaptations induced by obesity, cellular bioenergetics is currently considered a crucial target. New strategies to delay the onset of the hazardous adaptations induced by...
3.
Needs H, Glover E, Pereira G, Witt A, Hubner W, Dodding M, et al.
Nat Commun
. 2024 Feb;
15(1):988.
PMID: 38307874
Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the import machinery will disrupt their regenerative capacity and the cell's...
4.
Needs H, Lorriman J, Pereira G, Henley J, Collinson I
J Mol Biol
. 2023 Apr;
435(13):168129.
PMID: 37105499
Mitochondrial protein import is critical for organelle biogenesis, bioenergetic function, and health. The mechanism of which is poorly understood, particularly of the mammalian system. To address this problem we have...
5.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel I, Morris J, et al.
Nature
. 2023 Mar;
615(7952):499-506.
PMID: 36890229
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate....
6.
Ford H, Allen W, Pereira G, Liu X, Dillingham M, Collinson I
Elife
. 2022 Jun;
11.
PMID: 35674314
Nearly all mitochondrial proteins need to be targeted for import from the cytosol. For the majority, the first port of call is the translocase of the outer membrane (TOM complex),...
7.
Knapp-Wilson A, Pereira G, Buzzard E, Ford H, Richardson A, Corey R, et al.
J Cell Sci
. 2021 Jun;
134(13).
PMID: 34106255
Mitochondrial supercomplexes form around a conserved core of monomeric complex I and dimeric complex III; wherein a subunit of the former, NDUFA11, is conspicuously situated at the interface. We identified...
8.
Needs H, Protasoni M, Henley J, Prudent J, Collinson I, Pereira G
Life (Basel)
. 2021 Jun;
11(5).
PMID: 34064758
The fact that >99% of mitochondrial proteins are encoded by the nuclear genome and synthesised in the cytosol renders the process of mitochondrial protein import fundamental for normal organelle physiology....
9.
Pereira G, Lee L, Rawlings N, Ouwendijk J, Parker J, Andrienko T, et al.
PLoS One
. 2020 Jun;
15(6):e0234653.
PMID: 32579577
We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2 release is...
10.
Pereira G, Allen W, Watkins D, Buddrus L, Noone D, Liu X, et al.
J Mol Biol
. 2019 Mar;
431(8):1689-1699.
PMID: 30878481
Protein translocation is a fundamental process in biology. Major gaps in our understanding of this process arise due the poor sensitivity, low time resolution and irreproducibility of translocation assays. To...