Andrew P Gilmore
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Explore the profile of Andrew P Gilmore including associated specialties, affiliations and a list of published articles.
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36
Citations
1047
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Recent Articles
1.
Lingard E, Dong S, Hoyle A, Appleton E, Hales A, Skaria E, et al.
Biomater Adv
. 2024 Nov;
167:214111.
PMID: 39562212
No abstract available.
2.
Lingard E, Dong S, Hoyle A, Appleton E, Hales A, Skaria E, et al.
Biomater Adv
. 2024 Apr;
160:213847.
PMID: 38657288
Three-dimensional (3D) organoid models have been instrumental in understanding molecular mechanisms responsible for many cellular processes and diseases. However, established organic biomaterial scaffolds used for 3D hydrogel cultures, such as...
3.
King L, Rodriguez-Enriquez R, Pedley R, Mellor C, Wang P, Zindy E, et al.
Cell Death Differ
. 2022 May;
29(11):2262-2274.
PMID: 35585181
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer mitochondrial membrane (OMM) where they set the threshold for apoptosis,...
4.
Cao K, Riley J, Heilig R, Montes-Gomez A, Vringer E, Berthenet K, et al.
Dev Cell
. 2022 Apr;
57(10):1211-1225.e6.
PMID: 35447090
Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction promotes DNA damage under conditions of increased apoptotic priming. Underlying...
5.
Williams R, Jobling S, Sims A, Mou C, Wilkinson L, Collu G, et al.
Oncogene
. 2021 Dec;
41(7):1040-1049.
PMID: 34916592
Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and cutaneous glands. Here we...
6.
Pedley R, King L, Mallikarjun V, Wang P, Swift J, Brennan K, et al.
Cell Death Dis
. 2020 Oct;
11(10):872.
PMID: 33067418
Apoptotic priming controls the commitment of cells to apoptosis by determining how close they lie to mitochondrial permeabilisation. Variations in priming are important for how both healthy and cancer cells...
7.
Kuwana T, King L, Cosentino K, Suess J, Garcia-Saez A, Gilmore A, et al.
J Biol Chem
. 2020 Jan;
295(6):1623-1636.
PMID: 31901077
Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2-associated X...
8.
Wang P, Wu J, Wood A, Jones M, Pedley R, Li W, et al.
Sci Rep
. 2019 Dec;
9(1):18400.
PMID: 31804547
Vinculin is an essential component of cell adhesion complexes, where it regulates the strength and stability of adhesions. Whilst the role of vinculin in cell motility is well established, it...
9.
Gilbert H, Mallikarjun V, Dobre O, Jackson M, Pedley R, Gilmore A, et al.
Nat Commun
. 2019 Sep;
10(1):4149.
PMID: 31515493
Studies of cellular mechano-signaling have often utilized static models that do not fully replicate the dynamics of living tissues. Here, we examine the time-dependent response of primary human mesenchymal stem...
10.
E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death
Vuillier C, Lohard S, Fetiveau A, Allegre J, Kayaci C, King L, et al.
EMBO Rep
. 2017 Dec;
19(2):234-243.
PMID: 29233828
E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where...