Keith Brennan
Overview
Explore the profile of Keith Brennan including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1971
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0
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Recent Articles
1.
Scholfield S, Kavembe G, Duncan R, Ragama B, Mecha J, Orwa A, et al.
PLoS One
. 2023 Dec;
18(12):e0294202.
PMID: 38134188
We performed two cross-sectional surveys across three informal settlements in Kenya (within Kisii county, Nairobi, and Nakuru county) to study the effectiveness of public health interventions during the COVID-19 pandemic....
2.
Chen F, Gurler S, Novo D, Selli C, Alferez D, Eroglu S, et al.
Oncogene
. 2023 Jan;
42(9):679-692.
PMID: 36599922
Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by...
3.
King L, Rodriguez-Enriquez R, Pedley R, Mellor C, Wang P, Zindy E, et al.
Cell Death Differ
. 2022 May;
29(11):2262-2274.
PMID: 35585181
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer mitochondrial membrane (OMM) where they set the threshold for apoptosis,...
4.
Williams R, Jobling S, Sims A, Mou C, Wilkinson L, Collu G, et al.
Oncogene
. 2021 Dec;
41(7):1040-1049.
PMID: 34916592
Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and cutaneous glands. Here we...
5.
Edwards A, Brennan K
Front Cell Dev Biol
. 2021 Jul;
9:692173.
PMID: 34295896
The Notch signalling pathway is a highly conserved developmental signalling pathway, with vital roles in determining cell fate during embryonic development and tissue homeostasis. Aberrant Notch signalling has been implicated...
6.
Moruzzi M, Nestor-Bergmann A, Goddard G, Tarannum N, Brennan K, Woolner S
Curr Biol
. 2021 Jun;
31(15):3409-3418.e6.
PMID: 34111402
Epithelial tissues are highly sensitive to anisotropies in mechanical force, with cells altering fundamental behaviors, such as cell adhesion, migration, and cell division. It is well known that, in the...
7.
Acar A, Hidalgo-Sastre A, Leverentz M, Mills C, Woodcock S, Baron M, et al.
Sci Rep
. 2021 Apr;
11(1):9096.
PMID: 33907274
Notch and Wnt are two essential signalling pathways that help to shape animals during development and to sustain adult tissue homeostasis. Although they are often active at the same time...
8.
Peck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai P, et al.
Cancer Res
. 2021 Jan;
81(4):847-859.
PMID: 33509944
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this...
9.
Pedley R, King L, Mallikarjun V, Wang P, Swift J, Brennan K, et al.
Cell Death Dis
. 2020 Oct;
11(10):872.
PMID: 33067418
Apoptotic priming controls the commitment of cells to apoptosis by determining how close they lie to mitochondrial permeabilisation. Variations in priming are important for how both healthy and cancer cells...
10.
Borland S, Behnsen J, Ashton N, Francis S, Brennan K, Sherratt M, et al.
Int J Mol Sci
. 2020 Jul;
21(12).
PMID: 32630604
Vascular calcification describes the formation of mineralized tissue within the blood vessel wall, and it is highly associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease,...