Andrew N Chan
Overview
Explore the profile of Andrew N Chan including associated specialties, affiliations and a list of published articles.
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8
Citations
164
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0
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Recent Articles
1.
Chan A, Chen X, Falco J, Bak D, Weerapana E, Li B
ACS Chem Biol
. 2023 Aug;
18(9):1909-1914.
PMID: 37561838
The natural product holomycin contains a unique cyclic ene-disulfide and exhibits broad-spectrum antimicrobial activities. Reduced holomycin chelates metal ions with a high affinity and disrupts metal homeostasis in the cell....
2.
Johnson R, Chan A, Ward R, McGlade C, Hatfield B, Peters J, et al.
J Am Chem Soc
. 2021 Aug;
143(31):12003-12013.
PMID: 34342433
Hybrid antibiotics are an emerging antimicrobial strategy to overcome antibiotic resistance. The natural product thiomarinol A is a hybrid of two antibiotics: holothin, a dithiolopyrrolone (DTP), and marinolic acid, a...
3.
Hobson C, Chan A, Wright G
Chem Rev
. 2021 Feb;
121(6):3464-3494.
PMID: 33606500
The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria to acquire and develop an array of antibiotic resistance mechanisms. The sum of these resistance...
4.
Santa Maria K, Chan A, ONeill E, Li B
Chembiochem
. 2019 Jan;
20(11):1387-1393.
PMID: 30694017
The natural product pepticinnamin E potently inhibits protein farnesyl transferases and has potential applications in treating cancer and malaria. Pepticinnamin E contains a rare N-terminal cinnamoyl moiety as well as...
5.
Chan A, Wever W, Massolo E, Allen S, Li B
Chem Res Toxicol
. 2018 Dec;
32(3):400-404.
PMID: 30523678
The dithiolopyrrolone (DTP) natural products contain a unique ene-disulfide that is essential for their antimicrobial and anticancer activities. The ene-disulfide in some DTPs is oxidized to a cyclic thiosulfonate, but...
6.
Chan A, Shiver A, Wever W, Razvi S, Traxler M, Li B
Proc Natl Acad Sci U S A
. 2017 Feb;
114(10):2717-2722.
PMID: 28209778
Natural products harbor unique and complex structures that provide valuable antibiotic scaffolds. With an increase in antibiotic resistance, natural products once again hold promise for new antimicrobial therapies, especially those...
7.
Chan A, Santa Maria K, Li B
Curr Top Med Chem
. 2015 Oct;
16(15):1695-704.
PMID: 26456469
Microbes are important producers of natural products, which have played key roles in understanding biology and treating disease. However, the full potential of microbes to produce natural products has yet...
8.
Wever W, Bogart J, Baccile J, Chan A, Schroeder F, Bowers A
J Am Chem Soc
. 2015 Mar;
137(10):3494-7.
PMID: 25742119
Thiocillins from Bacillus cereus ATCC 14579 are members of the well-known thiazolyl peptide class of natural product antibiotics, the biosynthesis of which has recently been shown to proceed via post-translational...