Andrew McDavid
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Explore the profile of Andrew McDavid including associated specialties, affiliations and a list of published articles.
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33
Citations
2288
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Recent Articles
1.
Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe J, et al.
Nat Commun
. 2024 Jun;
15(1):4991.
PMID: 38862501
Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12...
2.
Sakaue S, Weinand K, Isaac S, Dey K, Jagadeesh K, Kanai M, et al.
Nat Genet
. 2024 Apr;
56(4):615-626.
PMID: 38594305
Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer-gene maps from disease-relevant tissues. Building enhancer-gene maps is essential but challenging with current experimental methods...
3.
Dunlap G, Wagner A, Meednu N, Zhang F, Jonsson A, Wei K, et al.
bioRxiv
. 2023 Mar;
PMID: 36993527
Rheumatoid arthritis (RA) is an autoimmune disease initiated by antigen-specific T cells and B cells, which promote synovial inflammation through a complex set of interactions with innate immune and stromal...
4.
Liu J, Lin X, McDavid A, Yang Y, Zhang H, Boyce B, et al.
Front Endocrinol (Lausanne)
. 2023 Mar;
14:1090049.
PMID: 36875448
Cellular senescence plays important roles in age-related diseases, including musculoskeletal disorders. Senescent cells (SCs) exert a senescence-associated secretory phenotype (SASP) by producing SASP factors, some of which overlap with factors...
5.
Lin X, Bell R, Catheline S, Takano T, McDavid A, Jonason J, et al.
Arthritis Rheumatol
. 2023 Jan;
75(6):923-936.
PMID: 36625730
Objective: The synovial lymphatic system (SLS) removes catabolic factors from the joint. Vascular endothelial growth factor C (VEGF-C) and its receptor, VEGFR-3, are crucial for lymphangiogenesis. However, their involvement in...
6.
Jonsson A, Zhang F, Dunlap G, Gomez-Rivas E, Watts G, Faust H, et al.
Sci Transl Med
. 2022 Jun;
14(649):eabo0686.
PMID: 35704599
T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T...
7.
Mattingly T, McDavid A, Wolf A, Lieber G, Solar R, Lee D, et al.
Front Neurol
. 2022 May;
13:874701.
PMID: 35547387
Background: Hypothermia remains the best studied neuroprotectant. Despite extensive positive large and small animal data, side effects continue to limit human applications. Selective hypothermia is an efficient way of applying...
8.
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, et al.
Cell Rep
. 2022 May;
39(5):110766.
PMID: 35508128
Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identify a...
9.
McDavid A, Laniewski N, Grier A, Gill A, Kessler H, Huyck H, et al.
iScience
. 2022 Mar;
25(4):104007.
PMID: 35310935
Neonatal immune-microbiota co-development is poorly understood, yet age-appropriate recognition of - and response to - pathogens and commensal microbiota is critical to health. In this longitudinal study of 148 preterm...
10.
Barnas J, Albrecht J, Meednu N, Alzamareh D, Baker C, McDavid A, et al.
J Immunol
. 2021 Oct;
207(11):2660-2672.
PMID: 34706932
Type I IFN is essential for viral clearance but also contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), via aberrant nucleic acid-sensing pathways, leading to...