Andrew Mancini
Overview
Explore the profile of Andrew Mancini including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
585
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0
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Recent Articles
1.
Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, et al.
Nature
. 2025 Jan;
PMID: 39778708
Oncogenic mutations that drive colorectal cancer can be present in healthy intestines for long periods without overt consequence. Mutation of Apc, the most common initiating event in conventional adenomas, activates...
2.
Kurtova A, Heinlein M, Haas S, Velten L, Dijkgraaf G, Storm E, et al.
Blood Adv
. 2022 Aug;
7(4):491-507.
PMID: 35914228
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones,...
3.
Amen A, Fellmann C, Soczek K, Ren S, Lew R, Knott G, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(13).
PMID: 33758097
Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase () promoter. promoter mutations create a binding site for a GA binding protein (GABP) transcription...
4.
Mancini A, Xavier-Magalhaes A, Woods W, Nguyen K, Amen A, Hayes J, et al.
Cancer Cell
. 2018 Sep;
34(3):513-528.e8.
PMID: 30205050
TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription...
5.
Ohba S, Mukherjee J, Johannessen T, Mancini A, Chow T, Wood M, et al.
Cancer Res
. 2016 Nov;
76(22):6680-6689.
PMID: 27758882
Mutations in the isocitrate dehydrogenase gene IDH1 are common in low-grade glioma, where they result in the production of 2-hydroxyglutarate (2HG), disrupted patterns of histone methylation, and gliomagenesis. IDH1 mutations...
6.
Bell R, Rube H, Xavier-Magalhaes A, Costa B, Mancini A, Song J, et al.
Mol Cancer Res
. 2016 Mar;
14(4):315-23.
PMID: 26941407
Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless proliferation driven by oncogenes. The recently discovered,...
7.
Bell R, Rube H, Kreig A, Mancini A, Fouse S, Nagarajan R, et al.
Science
. 2015 May;
348(6238):1036-9.
PMID: 25977370
Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the initiation of human cancer. Multiple cancer types, including...